Evidence map›Paper›PMID 27688663›Full record

Observational studyWorld journal of gastroenterology2016

FOCUS: Future of fecal calprotectin utility study in inflammatory bowel disease.

Greg Rosenfeld, Astrid-Jane Greenup, Andrew Round, Oliver Takach, Lawrence Halparin, Abid Saadeddin, Jin Kee Ho, Terry Lee, Robert Enns, Brian Bressler

Registry-linked trialAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in World journal of gastroenterology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03549988 (Pro-active Fecal Calprotectin Monitoring to Improve Patient Outcomes in Ulcerative Colitis), which is not on this map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03549988 completednot on this mapstarted 2018, after this paper: background citation

Pro-active Fecal Calprotectin Monitoring to Improve Patient Outcomes in Ulcerative Colitis: A Prospective Randomised Control Trial

TypeobservationalSponsorUniversity of British ColumbiaRan2018 to 2025Enrolled726ConditionsUlcerative ColitisArmsFecal Calprotectin (FC) measurements with IBDocTM
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Observational
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Greg RosenfeldGreg Rosenfeld, Astrid-Jane Greenup, Andrew Round, Oliver Takach, Lawrence Halparin, Robert Enns, Brian Bressler, Department of Medicine, Division of Gastroenterology, St. Paul's Hospital, University of British Columbia, Vancouver, BC V6Z 2K5, Canada.
Astrid-Jane GreenupGreg Rosenfeld, Astrid-Jane Greenup, Andrew Round, Oliver Takach, Lawrence Halparin, Robert Enns, Brian Bressler, Department of Medicine, Division of Gastroenterology, St. Paul's Hospital, University of British Columbia, Vancouver, BC V6Z 2K5, Canada.
Andrew RoundGreg Rosenfeld, Astrid-Jane Greenup, Andrew Round, Oliver Takach, Lawrence Halparin, Robert Enns, Brian Bressler, Department of Medicine, Division of Gastroenterology, St. Paul's Hospital, University of British Columbia, Vancouver, BC V6Z 2K5, Canada.
Oliver TakachGreg Rosenfeld, Astrid-Jane Greenup, Andrew Round, Oliver Takach, Lawrence Halparin, Robert Enns, Brian Bressler, Department of Medicine, Division of Gastroenterology, St. Paul's Hospital, University of British Columbia, Vancouver, BC V6Z 2K5, Canada.
Lawrence HalparinGreg Rosenfeld, Astrid-Jane Greenup, Andrew Round, Oliver Takach, Lawrence Halparin, Robert Enns, Brian Bressler, Department of Medicine, Division of Gastroenterology, St. Paul's Hospital, University of British Columbia, Vancouver, BC V6Z 2K5, Canada.
Abid SaadeddinGreg Rosenfeld, Astrid-Jane Greenup, Andrew Round, Oliver Takach, Lawrence Halparin, Robert Enns, Brian Bressler, Department of Medicine, Division of Gastroenterology, St. Paul's Hospital, University of British Columbia, Vancouver, BC V6Z 2K5, Canada.
Jin Kee HoGreg Rosenfeld, Astrid-Jane Greenup, Andrew Round, Oliver Takach, Lawrence Halparin, Robert Enns, Brian Bressler, Department of Medicine, Division of Gastroenterology, St. Paul's Hospital, University of British Columbia, Vancouver, BC V6Z 2K5, Canada.
Terry LeeGreg Rosenfeld, Astrid-Jane Greenup, Andrew Round, Oliver Takach, Lawrence Halparin, Robert Enns, Brian Bressler, Department of Medicine, Division of Gastroenterology, St. Paul's Hospital, University of British Columbia, Vancouver, BC V6Z 2K5, Canada.
Robert EnnsGreg Rosenfeld, Astrid-Jane Greenup, Andrew Round, Oliver Takach, Lawrence Halparin, Robert Enns, Brian Bressler, Department of Medicine, Division of Gastroenterology, St. Paul's Hospital, University of British Columbia, Vancouver, BC V6Z 2K5, Canada.
Brian BresslerGreg Rosenfeld, Astrid-Jane Greenup, Andrew Round, Oliver Takach, Lawrence Halparin, Robert Enns, Brian Bressler, Department of Medicine, Division of Gastroenterology, St. Paul's Hospital, University of British Columbia, Vancouver, BC V6Z 2K5, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo evaluate the perspective of gastroenterologists regarding the impact of fecal calprotectin (FC) on the management of patients with inflammatory bowel disease (IBD).

methodsPatients with known IBD or symptoms suggestive of IBD for whom the physician identified that FC would be clinically useful were recruited. Physicians completed an online "pre survey" outlining their rationale for the test. After receipt of the test results, the physicians completed an online "post survey" to portray their perceived impact of the test result on patient management. Clinical outcomes for a subset of patients with follow-up data available beyond the completion of the "post survey" were collected and analyzed.

resultsOf 373 test kits distributed, 290 were returned, resulting in 279 fully completed surveys. One hundred and ninety patients were known to have IBD; 147 (77%) with Crohn's Disease, 43 (21%) Ulcerative Colitis and 5 (2%) IBD unclassified. Indications for FC testing included: 90 (32.2%) to differentiate a new diagnosis of IBD from Irritable Bowel Syndrome (IBS), 85 (30.5%) to distinguish symptoms of IBS from IBD in those known to have IBD and 104 (37.2%) as an objective measure of inflammation. FC levels resulted in a change in management 51.3% (143/279) of the time which included a significant reduction in the number of colonoscopies (118) performed (P < 0.001). Overall, 97.5% (272/279) of the time, the physicians found the test sufficiently useful that they would order it again in similar situations. Follow-up data was available for 172 patients with further support for the clinical utility of FC provided.

conclusionThe FC test effected a change in management 51.3% of the time and receipt of the result was associated with a reduction in the number of colonoscopies performed.

Indexed as

AdultAgedBiomarkersBritish ColumbiaColitis, UlcerativeColonoscopyCrohn DiseaseFecesFemaleHumansInflammationInflammatory Bowel DiseasesLeukocyte L1 Antigen ComplexMaleMiddle AgedProspective StudiesBiomarkersLeukocyte L1 Antigen ComplexBiomarkersColonoscopyFecal calprotectinInflammatory bowel diseasePhysician perspective

Identifiers

PMID27688663
PMCPMC5037090

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.