Evidence map›Paper›PMID 27688594›Full record

ArticleOtorinolaringologia2015

The P1 biomarker for assessing cortical maturation in pediatric hearing loss: a review.

Anu Sharma, Hannah Glick, Emily Deeves, Erin Duncan

Abstract read
In one paragraph

Article in Otorinolaringologia, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. P1 cortical auditory evoked potential in children with unilateral or bilateral cochlear implants; implication for the timing of second cochlear implantation.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2018
    Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Anu SharmaBrain & Behavior Laboratory, Department of Speech, Language, & Hearing Science and Institute of Cognitive Science, University of Colorado, 2501 Kittredge Loop Road, 409 UCB, Boulder, CO 80309, USA.
Hannah GlickBrain & Behavior Laboratory, Department of Speech, Language, & Hearing Science and Institute of Cognitive Science, University of Colorado, 2501 Kittredge Loop Road, 409 UCB, Boulder, CO 80309, USA.
Emily DeevesBrain & Behavior Laboratory, Department of Speech, Language, & Hearing Science and Institute of Cognitive Science, University of Colorado, 2501 Kittredge Loop Road, 409 UCB, Boulder, CO 80309, USA.
Erin DuncanBrain & Behavior Laboratory, Department of Speech, Language, & Hearing Science and Institute of Cognitive Science, University of Colorado, 2501 Kittredge Loop Road, 409 UCB, Boulder, CO 80309, USA.

Funding

Institutional Training in Otolaryngology ResearchT32DC012280 · NIDCD · UNIVERSITY OF COLORADO DENVER · PI Yuri Agrawal, Sue C. Kinnamon · 2013 to 2026
$3.4M
Central Auditory Development in Hearing Impaired InfantsR01DC006257 · NIDCD · UNIVERSITY OF TEXAS DALLAS · PI SHARMA, ANU · 2004 to 2009
$2.6M
NIDCD NIH HHS R01 DC006257NIDCD NIH HHS T32 DC012280
6 · The paper itself

Abstract

We review evidence for a high degree of neuroplasticity of the central auditory pathways in early childhood, citing evidence of studies of the P1 and N1 cortical auditory evoked potentials in congenitally deaf children receiving cochlear implants at different ages during childhood, children with auditory neuropathy spectrum disorder and children with hearing loss and comorbid multiple disabilities. We discuss neuroplasticity, including cortico-cortical de-coupling and cross-modal re-organization that occurs in deafness. We provide evidence for the clinical utility of the P1 cortical auditory evoked potential (CAEP) as a non-invasive biomarker that can be used to objectively assess maturation of auditory cortex in clinical cases of cochlear implant patients and candidates. Finally, we present clinical case studies in which the P1 CAEP biomarker proved useful in clinical decision-making regarding intervention in cases of single-sided deafness, auditory neuropathy spectrum disorder, mild hearing loss and hypoplastic auditory nerve.

Indexed as

Auditory CortexBiomarkersCochlear implantsNeuronal Plasticity

Identifiers

PMID27688594
PMCPMC5036577

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.