Evidence map›Paper›PMID 27688567›Full record

ArticleMedical journal, Armed Forces India2008

Use of Anti-Craving Agents in Soldiers with Alcohol Dependence Syndrome.

P L Narayana, A K Gupta, P K Sharma

Open access · bronzeAbstract read
In one paragraph

Article in Medical journal, Armed Forces India, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Anticonvulsants for alcohol dependence.The Cochrane database of systematic reviews · 2014
    Pooled it
  2. Critical needs in drug discovery for cessation of alcohol and nicotine polysubstance abuse.Progress in neuro-psychopharmacology & biological psychiatry · 2016
    Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

P L NarayanaClassified Specialist and HOD (Psychiatry), AFCME, Subroto Park, New Delhi-110010.
A K GuptaClassified Specialist (Psychiatry), Command Hospital (NC), Udhampur.
P K SharmaClassified Specialist and HOD (Psychiatry), 5 Air Force Hospital, Jorhat, Assam.
Command Hospital Air Force · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn a search for an effective 'anti-alcohol pill', three modern anti-craving agents have been studied in alcoholics of Army/ DSC, Air Force, Navy and Coast Guard.

methods129 patients of alcohol dependence syndrome were randomly assigned to three groups where topiramate, acamprosate and naltrexone were used as anti-craving agents in a year long prospective study. Of these 92 patients completed the study. RESULT AND

conclusionTopiramate (76.3%) appears to be significantly more effective (p<0.01) in sustaining abstinence, though naltrexone (57.7%) and acamprosate (60.70%) offer moderate relapse-prevention efficacy. Side effects of all the three agents have been mild, transient and self-limiting. We recommend a trial of topiramate, before invaliding out of any alcoholic soldier.

Indexed as

AcamprosateAlcohol dependence syndromeNaltrexoneTopiramate

Identifiers

PMID27688567
PMCPMC5035271
OpenAlexW1967231563

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.