ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2017
Impact of Aging on Proprioceptive Sensory Neurons and Intrafusal Muscle Fibers in Mice.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 51 citations in OpenAlex.
- Age-related changes and lack of effect of midlife resistance wheel exercise on afferent connectivity of lumbar alpha motor neurons in ageing mouse spinal cord.Biogerontology · 2025Article
- Molecular Framework of the Onset and Progression of Skeletal Muscle Aging.International journal of molecular sciences · 2025Review
- Ageing changes the proprioceptive contribution to balance control under different types of mastoid vibration: A cross-sectional study.Experimental physiology · 2025Article
- Muscle spindle afferent neurons preferentially degenerate with aging.Scientific reports · 2025Article
- Contributions and future potential of animal models for geroscience research on sensory systems.GeroScience · 2025Review
- Posture control characteristics of different age groups in China based on BertecFrontiers in neurology · 2025Article
- Differential disruptions in population coding along the dorsal-ventral axis of CA1 in the APP/PS1 mouse model of Aβ pathology.PLoS computational biology · 2024Article
- Characterising vincristine-induced peripheral neuropathy in adults: symptom development and long-term persistent outcomes.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Article
- Age-associated changes in lineage composition of the enteric nervous system regulate gut health and disease.eLife · 2023Article
- Facilitation-inhibition control of motor neuronal persistent inward currents in young and older adults.The Journal of physiology · 2022Article
- Proprioception and Geriatric Low Back Pain.Spine surgery and related research · 2022Review
- Electromyographic responses to unexpected Achilles tendon vibration-induced perturbations during standing in young and older people.Experimental brain research · 2022Article
- Exercise-mediated reinnervation of skeletal muscle in elderly people: An update.European journal of translational myology · 2022Article
- Age-Related Alterations of Hyaluronan and Collagen in Extracellular Matrix of the Muscle Spindles.Journal of clinical medicine · 2021Article
- Article
- Muscle spindle function in healthy and diseased muscle.Skeletal muscle · 2021Review
- The Hamstrings: Anatomic and Physiologic Variations and Their Potential Relationships With Injury Risk.Frontiers in physiology · 2021Review
- Motoneuron deafferentation and gliosis occur in association with neuromuscular regressive changes during ageing in mice.Journal of cachexia, sarcopenia and muscle · 2020Article
- Exercise-linked improvement in age-associated loss of balance is associated with increased vestibular input to motor neurons.Aging cell · 2020Article
- The Influence of Neuron-Extrinsic Factors and Aging on Injury Progression and Axonal Repair in the Central Nervous System.Frontiers in cell and developmental biology · 2020Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The impact of aging on proprioceptive sensory neurons and intrafusal muscle fibers (IMFs) remains largely unexplored despite the central function these cells play in modulating voluntary movements. Here, we show that proprioceptive sensory neurons undergo deleterious morphological changes in middle age (11- to 13-month-old) and old (15- to 21-month-old) mice. In the extensor digitorum longus and soleus muscles of middle age and old mice, there is a significant increase in the number of Ia afferents with large swellings that fail to properly wrap around IMFs compared with young adult (2- to 4-month-old) mice. Fewer II afferents were also found in the same muscles of middle age and old mice. Although these age-related changes in peripheral nerve endings were accompanied by degeneration of proprioceptive sensory neuron cell bodies in dorsal root ganglia (DRG), the morphology and number of IMFs remained unchanged. Our analysis also revealed normal levels of neurotrophin 3 (NT3) but dysregulated expression of the tyrosine kinase receptor C (TrkC) in aged muscles and DRGs, respectively. These results show that proprioceptive sensory neurons degenerate prior to atrophy of IMFs during aging, and in the presence of the NT3/TrkC signaling axis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.