Evidence map›Paper›PMID 27688400›Full record

ArticleGenes & development2016

Neuron type-specific miRNA represses two broadly expressed genes to modulate an avoidance behavior in C. elegans.

Tanja Drexel, Katharina Mahofsky, Richard Latham, Manuel Zimmer, Luisa Cochella

Open access · diamondAbstract read
In one paragraph

Article in Genes & development, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. MicroRNA-Dependent Control of Sensory Neuron Function Regulates Posture Behavior inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Article
  11. Article
  12. Article
  13. Review
  14. The multifaceted roles of microRNAs in differentiation.Current opinion in cell biology · 2020
    Review
  15. Article
  16. Review
  17. MicroRNAs: From Mechanism to Organism.Frontiers in cell and developmental biology · 2020
    Review
  18. TheGenetics · 2019
    Review
  19. Life science alliance · 2019
    Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Tanja DrexelResearch Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), 1030 Vienna, Austria.
Katharina MahofskyResearch Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), 1030 Vienna, Austria.
Richard LathamResearch Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), 1030 Vienna, Austria.
Manuel ZimmerResearch Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), 1030 Vienna, Austria.
Luisa CochellaResearch Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), 1030 Vienna, Austria.ORCID http://orcid.org/0000-0003-4018-7722
Research Institute of Molecular Pathology · AT

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
European Research Council 337161NIH HHS P40 OD010440
6 · The paper itself

Abstract

Two broad gene classes are distinguished within multicellular organisms: cell type-specific genes, which confer particular cellular properties, and ubiquitous genes that support general cellular functions. However, certain so-called ubiquitous genes show functionally relevant cell type-specific repression. How such repression is achieved is poorly understood. MicroRNAs (miRNAs) are repressors, many of which are expressed with high cell type specificity. Here we show that mir-791, expressed exclusively in the CO

Indexed as

Behavior, AnimalGene Expression Regulation, DevelopmentalAnimalsAvoidance LearningCaenorhabditis elegansCaenorhabditis elegans ProteinsCarbon DioxideMicroRNAsSensory Receptor CellsCaenorhabditis elegans ProteinsCarbon DioxideMicroRNAsMIRN791 microRNA, C eleganscarbon dioxideC. eleganscell identitymiRNAs

Identifiers

PMID27688400
PMCPMC5066611
OpenAlexW2525686694

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.