Evidence map›Paper›PMID 27688368›Full record

ArticleActa stomatologica Croatica2014

A Fast Method for DEFB1 - 44C/G SNP Genotyping in Brazilian Patients with Periodontitis.

Renata Cimőes, Rafael Rafael Amorim Cavalcanti de Siqueira, Sergio Crovella, Paulo Roberto Eleutério de Souza, Nikos Donos

Open access · diamondAbstract read
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In one paragraph

Article in Acta stomatologica Croatica, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 92% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Renata CimőesPhD, Federal University of Pernambuco, Recife, Brazil.
Rafael Rafael Amorim Cavalcanti de SiqueiraPost-Graduate Student, Federal University of Pernambuco, Recife, Brazil.
Sergio CrovellaPhD, Federal University of Pernambuco, Recife, Brazil.
Paulo Roberto Eleutério de SouzaPhD, Federal Rural University of Pernambuco, Recife, Brazil.
Nikos DonosPhD, Eastman Dental Institute, Unit Periodontology, London, United Kingdom.
Centro Universitário da Cidade · BRUniversidade Federal de Pernambuco · BREastman Dental Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimDefensins are cationic antimicrobial peptides expressed in epithelial cells. Such peptides exhibit antibacterial, antifungal and antiviral properties, and are a component of the innate immune response. It has been suggested that they have a protective role in the oral cavity. This study evaluated the DEFB1 polymorphism in diabetic patients with or without periodontitis in comparison to healthy controls. MATERIAL AND

methodsWe used Hairpin-Shaped Primer (HP) assay to study the distribution of the -44 C/G SNP (rs1800972) in 119 human DNAs obtained from diabetic patients and healthy control patients.

resultsThe results indicate that there are no differences in distribution between groups and that in diabetic periodontitis patients the homozygous mutant could be found more frequently.

conclusionFurther studies are necessary in order to investigate the role of DEFB1 polymorphisms in diabetic periodontitis patients and the influence of the peptide in periodontal pathogens.

Indexed as

Antimicrobial Cationic PeptidesDEFB1 ProteinDefensinsDiabetes ComplicationsEpithelial CellsHumansPeriodontitis

Identifiers

PMID27688368
PMCPMC4872829
OpenAlexW1971915124

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.