ArticleVascular medicine (London, England)2016
WNT5A-JNK regulation of vascular insulin resistance in human obesity.
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Article in Vascular medicine (London, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
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Who cites it
29 citing papers in PubMed, 38 citations in OpenAlex.
- Systems genetics reveals ITIH5 as a key mediator of adipocyte-Endothelial crosstalk.Molecular metabolism · 2026Article
- Attack of the kinases: JNK signaling in metabolism.American journal of physiology. Regulatory, integrative and comparative physiology · 2026Review
- Maternal probiotic and prebiotic supplementation on glucose metabolism in pregnant women and their offspring: effects and related mechanisms.Frontiers in microbiology · 2026Review
- The Adipokine Hypothesis of Heart Failure With a Preserved Ejection Fraction: A Novel Framework to Explain Pathogenesis and Guide Treatment.Journal of the American College of Cardiology · 2025Review
- Unraveling the Role of the Wnt Pathway in Hepatocellular Carcinoma: From Molecular Mechanisms to Therapeutic Implications.Journal of clinical and translational hepatology · 2025Review
- Wnt Signaling in Atherosclerosis: Mechanisms to Therapeutic Implications.Biomedicines · 2024Review
- Review
- Distinctive Signs of Disease as Deterrents for the Endothelial Function: A Systematic Review.Metabolites · 2023Review
- Non-canonical WNT signalling in cardiovascular disease: mechanisms and therapeutic implications.Nature reviews. Cardiology · 2022Review
- The Emerging Role of Sfrp5 and Wnt5a in the Pathogenesis of Obesity: Implications for a Healthy Diet and Lifestyle.Nutrients · 2021Review
- The complex role of Wnt ligands in type 2 diabetes mellitus and related complications.Journal of cellular and molecular medicine · 2021Review
- Role of Wnt signaling pathways in type 2 diabetes mellitus.Molecular and cellular biochemistry · 2021Review
- Perivascular Adipose Tissue Inflammation in Ischemic Heart Disease.Arteriosclerosis, thrombosis, and vascular biology · 2021Article
- Leptin improves intestinal flora dysfunction in mice with high-fat diet-induced obesity.The Journal of international medical research · 2020Article
- Correlation Between Circulating Levels of Secreted Frizzled-Related Protein 5 and Type 2 Diabetic Patients and Subjects with Impaired-Glucose Regulation.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
- Islet Stellate Cells Regulate Insulin Secretion via Wnt5a in Min6 Cells.International journal of endocrinology · 2020Article
- Identification of Nonylphenol and Glucolipid Metabolism-Related Proteins in the Serum of Type 2 Diabetes Patients.Iranian journal of public health · 2019Article
- Adipose tissue-derived WNT5A regulates vascular redox signaling in obesity via USP17/RAC1-mediated activation of NADPH oxidases.Science translational medicine · 2019Article
- Wnt5a-Mediated Neutrophil Recruitment Has an Obligatory Role in Pressure Overload-Induced Cardiac Dysfunction.Circulation · 2019Article
- JNK and cardiometabolic dysfunction.Bioscience reports · 2019Review
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Authors and funding
14 authors at 1 institution in 1 country.
Melissa G FarbDepartment of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA, USA.
Shakun KarkiDepartment of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA, USA.
Song-Young ParkDepartment of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA, USA.
Samantha M SaggeseDepartment of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA, USA.
Brian CarmineDepartment of General Surgery, Boston University School of Medicine, Boston, MA, USA.
Donald T HessDepartment of General Surgery, Boston University School of Medicine, Boston, MA, USA.
Caroline ApovianDepartment of Medicine, Section of Endocrinology, Diabetes and Nutrition, Boston University School of Medicine, Boston, MA, USA.
Jessica L FettermanDepartment of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA, USA.
Rosa Bretón-RomeroDepartment of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA, USA.
Naomi M HamburgDepartment of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA, USA.
José J FusterDepartment of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA, USA.
María A ZuriagaDepartment of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA, USA.
Kenneth WalshDepartment of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA, USA.
Noyan GokceDepartment of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA, USA Noyan.Gokce@bmc.org.
Boston University · US
Funding
Redox regulation in Endothelial Progenitor CellsP01HL081587 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI WALSH, KENNETH · 2005 to 2015
$21.5MMultidisciplinary Training in Cardiovascular ResearchT32HL007224 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI HAMBURG, NAOMI MIRIAM, WAINFORD, RICHARD DAVID · 1985 to 2020
$12.3MMitochondrial Dynamics and UCP2 - Endothelial Dysfunction in Human ObesityR01HL115391 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI HAMBURG, NAOMI MIRIAM · 2013 to 2017
$2.8MAnti-Angiogenic Mechanisms in Human ObesityR01HL126141 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI GOKCE, NOYAN, WALSH, KENNETH · 2015 to 2019
$2.4MAdipose inflammation, mitochondrial function & endothelial phenotypes in obesityR01HL114675 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI GOKCE, NOYAN · 2012 to 2016
$2.3MInflammatory Wnt signaling in ischemic myocardiumR01HL131006 · NHLBI · UNIVERSITY OF VIRGINIA · PI WALSH, KENNETH · 2016 to 2019
$2.1MInflammatory Pathways in Aortic AneurysmsR01HL132564 · NHLBI · UNIVERSITY OF VIRGINIA · PI WALSH, KENNETH · 2016 to 2019
$1.9MMitochondrial dynamics and cardiac remodelingR01HL120160 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI WALSH, KENNETH · 2013 to 2016
$1.6MDeterminants of obesity-associated insulin resistanceK23HL135394 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI FARB, MELISSA G · 2017 to 2021
$895kMyokine Control of Hepatic SteatosisR21AG052160 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI WALSH, KENNETH · 2016 to 2017
$452kNHLBI NIH HHS K23 HL135394NHLBI NIH HHS P01 HL081587NHLBI NIH HHS R01 HL114675NHLBI NIH HHS R01 HL115391NHLBI NIH HHS R01 HL120160NHLBI NIH HHS R01 HL126141NHLBI NIH HHS R01 HL131006NHLBI NIH HHS R01 HL132564NHLBI NIH HHS T32 HL007224NIA NIH HHS R21 AG052160
Abstract
Obesity is associated with the development of vascular insulin resistance; however, pathophysiological mechanisms are poorly understood. We sought to investigate the role of WNT5A-JNK in the regulation of insulin-mediated vasodilator responses in human adipose tissue arterioles prone to endothelial dysfunction. In 43 severely obese (BMI 44±11 kg/m
Indexed as
AdiposityInsulin ResistanceAdolescentAdultArteriolesCase-Control StudiesCells, CulturedEndothelium, VascularFemaleHumansInsulinIntra-Abdominal FatIn Vitro TechniquesJNK Mitogen-Activated Protein KinasesMaleMiddle AgedInsulinJNK Mitogen-Activated Protein KinasesNitric Oxide Synthase Type IIINOS3 protein, humanProtein Kinase InhibitorsVasodilator AgentsWnt-5a ProteinWNT5A protein, humanendotheliuminsulin resistancenitric oxideobesity
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.