ArticleNeuroImage2018
Individualized parcellation of the subthalamic nucleus in patients with Parkinson's disease with 7T MRI.
Article in NeuroImage, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 1 of them a synthesis that pooled it.
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Who cites it
79 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Present and Future of Ultra-High Field MRI in Neurodegenerative Disorders.Current neurology and neuroscience reports · 2018Pooled it
- Multiscale characterization of the human claustrum from histology to MRI.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
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- Dynamic Reconfiguration of Cognitive Networks and Recovery From Microlesion Effects in Parkinson's Disease: Insights From a Longitudinal fNIRS Study.CNS neuroscience & therapeutics · 2026Article
- A novel methodology for localizing pallidal deep brain stimulation leads.Frontiers in neuroanatomy · 2026Article
- From lobotomy to connectomics: a critical review of contemporary psychosurgery.Frontiers in psychiatry · 2026Review
- Advanced MRI for targeting the pallidothalamic region in magnetic resonance-guided focused ultrasound: the mammillothalamic tract as an adjacent imaging landmark.Frontiers in radiology · 2026Review
- Article
- Lower limb motor effects of DBS neurofeedback in Parkinson's disease assessed through IMU-based UPDRS movement quality metrics.Scientific reports · 2025Article
- Precise Electrode Co-Alignment in Deep Brain Stimulation Fusing Neuroimaging and Electrophysiology.The European journal of neuroscience · 2025Article
- Effective Functional Pattern Between Prefrontal fNIRS Activity and Cognitive Performance in Patients With Parkinson's Disease: A Data-Driven PLS Approach.Brain and behavior · 2025Article
- Comparison of structural connectomes for modeling deep brain stimulation pathway activation.NeuroImage · 2025Article
- Structural Connectivity of the Basal Ganglia from Patient-Individual Tractography Is Key for Understanding the Effects of Deep Brain Stimulation in Parkinson's Disease.Stereotactic and functional neurosurgery · 2025Article
- GOUHFI: A novel contrast- and resolution-agnostic segmentation tool for ultra-high-field MRI.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Neuroimaging and fluid biomarkers in Parkinson's disease in an era of targeted interventions.Nature communications · 2024Review
- Prior-guided individualized thalamic parcellation based on local diffusion characteristics.Human brain mapping · 2024Article
- Architecture of the subthalamic nucleus.Communications biology · 2024Review
- Focused stimulation of dorsal versus ventral subthalamic nucleus enhances action-outcome learning in patients with Parkinson's disease.Brain communications · 2024Article
- Contribution of the subthalamic nucleus to motor, cognitive and limbic processes: an electrophysiological and stimulation study in monkeys.Frontiers in neuroscience · 2024Article
19 more citing papers are in PubMed but not listed here.
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Authors and funding
11 authors.
Funding
Abstract
Deep brain stimulation of the subthalamic nucleus (STN) is a widely performed surgical treatment for patients with Parkinson's disease. The goal of the surgery is to place an electrode centered in the motor region of the STN while lowering the effects of electrical stimulation on the non-motor regions. However, distinguishing the motor region from the neighboring associative and limbic areas in individual patients using imaging modalities was until recently difficult to obtain in vivo. Here, using ultra-high field MR imaging, we have performed a dissection of the subdivisions of the STN of individual Parkinson's disease patients. We have acquired 7T diffusion-weighted images of seventeen patients with Parkinson's disease scheduled for deep brain stimulation surgery. Using a structural connectivity-based parcellation protocol, the STN's connections to the motor, limbic, and associative cortical areas were used to map the individual subdivisions of the nucleus. A reproducible patient-specific parcellation of the STN into a posterolateral motor and gradually overlapping central associative area was found in all STNs, taking up on average 55.3% and 55.6% of the total nucleus volume. The limbic area was found in the anteromedial part of the nucleus. Our results suggest that 7T MR imaging may facilitate individualized and highly specific planning of deep brain stimulation surgery of the STN.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.