Evidence map›Paper›PMID 27688144›Full record

ArticleAIDS and behavior2017

Sex Disparities in Adverse Childhood Experiences and HIV/STIs: Mediation of Psychopathology and Sexual Behaviors.

Monique J Brown, Saba W Masho, Robert A Perera, Briana Mezuk, River A Pugsley, Steven A Cohen

Open access · greenAbstract read
In one paragraph

Article in AIDS and behavior, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Childhood Sexual Trauma, Substance Use, and Antiretroviral Therapy Adherence Among Older Adults Living With HIV: A Mediational Analysis.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Childhood Sexual Trauma and Subjective Cognitive Decline: An Assessment of Racial/Ethnic and Sexual Orientation Disparities.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2023
    Article
  13. Adverse Childhood Experiences and Mental Health among Students Seeking Psychological Counseling Services.International journal of environmental research and public health · 2023
    Article
  14. Article
  15. Adverse Childhood Experiences among a Sample of Youth Living with HIV in the Deep South.International journal of environmental research and public health · 2022
    Article
  16. Article
  17. Article
  18. Adverse Childhood Experiences and Subjective Cognitive Decline in the US.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2022
    Article
  19. Article
  20. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Monique J BrownCollege of Behavioral and Community Sciences, University of South Florida, 13301 Bruce B. Downs Blvd, MHC 2503, Tampa, FL, 33612, USA. brownm3@usf.edu.
Saba W MashoDivision of Epidemiology, Department of Family Medicine and Population Health, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.
Robert A PereraDepartment of Biostatistics, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.
Briana MezukCollege of Behavioral and Community Sciences, University of South Florida, 13301 Bruce B. Downs Blvd, MHC 2503, Tampa, FL, 33612, USA.
River A PugsleyOffice of Epidemiology, Division of Disease Prevention, Virginia Department of Health, Richmond, VA, USA.
Steven A CohenHealth Studies, University of Rhode Island, Kingston, RI, USA.
University of South Florida · USVirginia Commonwealth University · USUniversity of Rhode Island · USVirginia Department of Health · US

Funding

Depression, inflammation, and diabetes: Exploring shared etiopathologyK01MH093642 · NIMH · VIRGINIA COMMONWEALTH UNIVERSITY · PI MEZUK, BRIANA · 2012 to 2015
$689k
NIMH NIH HHS K01 MH093642
6 · The paper itself

Abstract

HIV and other sexually transmitted infections (STIs) are important public health challenges in the US. Adverse childhood experiences (ACEs), including abuse (emotional, physical or sexual), witnessing violence among household members, may have an effect on sexual behaviors, which increase the risk of HIV/STIs. The aim of this study was to examine the sex differences in the role of posttraumatic stress disorder (PTSD), major depression (MD), substance use disorders (SUDs), early sexual debut, and intimate partner violence (IPV) perpetration as mediators in the association between ACEs and HIV/STIs. Data were obtained from Wave 2 (2004-2005) of the National Epidemiologic Survey on Alcohol and Related Conditions. Structural equation modeling was used to determine the role of PTSD, MD, SUDs, early sexual debut, and IPV perpetration as mediators in the relationships between ACEs and HIV/STIs. Differences and similarities existed in the mediational roles of psychopathology and sexual behaviors. For example, among men, MD fully mediated physical/psychological abuse (β = 0.0002; p = 0.012) and sexual abuse (β = 0.0002; p = 0.006), and HIV/STIs while among women, MD fully mediated physical/psychological abuse (β = 0.0005; p < 0.001) and parental violence (β = -0.0002; p = 0.012). Among men, IPV perpetration fully mediated sexual abuse (β = -0.0005; p = 0.012) and HIV/STIs while among women, IPV perpetration was not a statistically significant mediator. HIV/STI prevention and intervention programs should use a life course approach by addressing adverse childhood events among men and women and consider the sex differences in the roles of psychopathology and sexual behaviors.

Indexed as

Life Change EventsMajor Depressive DisorderAdultChildChild AbuseChild Abuse, SexualCross-Sectional StudiesFemaleHIV InfectionsHumansIntimate Partner ViolenceMaleMiddle AgedSexual BehaviorSpouse AbuseStress Disorders, Post-TraumaticChild abuseHIVMediationMenSexually transmitted diseasesWomen

Identifiers

PMID27688144
PMCPMC5896316
OpenAlexW2525609043

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.