ReviewAlcoholism, clinical and experimental research2016
Moderate Alcohol Consumption and Chronic Disease: The Case for a Long-Term Trial.
Review in Alcoholism, clinical and experimental research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03169530 (Moderate Alcohol and Cardiovascular Health Trial), which is not on this map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Moderate Alcohol and Cardiovascular Health Trial
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Association of alcohol consumption with morbidity and mortality in patients with cardiovascular disease: original data and meta-analysis of 48,423 men and women.BMC medicine · 2021Pooled it
- The Effects of Alcohol Consumption on Cardiometabolic Health Outcomes Following Weight Loss in Premenopausal Women with Obesity: A Pilot Randomized Controlled Trial.International journal of environmental research and public health · 2020Trial
- Alcohol Consumption and Cardiovascular Disease: A Narrative Review of Evolving Perspectives and Long-Term Implications.Life (Basel, Switzerland) · 2024Review
- Ethanol's impact on the brain: a neurobiological perspective on the mechanisms of memory impairment.Molecular biology reports · 2024Review
- Principles of engagement on research and other collaborations between the brewing sector and research entities: the FACT Principles.The British journal of nutrition · 2023Article
- Alcohol Consumption and Risk of Total Hip Replacement Due to Hip Osteoarthritis in Women.Arthritis & rheumatology (Hoboken, N.J.) · 2023Article
- Effects of moderate ethanol consumption as a function of n-6:n-3 dietary ratio on lipid profile, inflammation, and liver function in mice.International journal of cardiology. Cardiovascular risk and prevention · 2022Article
- Alcohol, Drinking Pattern, and Chronic Disease.Nutrients · 2022Review
- Food insecurity and the role of food assistance programs in supporting diet quality during the COVID-19 pandemic in Massachusetts.Frontiers in nutrition · 2022Article
- Alcohol, cardiovascular disease and industry funding: A co-authorship network analysis of systematic reviews.Social science & medicine (1982) · 2021Article
- The Moderate Alcohol and Cardiovascular Health Trial (MACH15): Design and methods for a randomized trial of moderate alcohol consumption and cardiometabolic risk.European journal of preventive cardiology · 2020Article
- Association of Food and Alcohol Consumption with Peripheral Atherosclerotic Plaque Volume as Measured by 3D-Ultrasound.Nutrients · 2020Observational
- Alcohol Industry Involvement in the Moderate Alcohol and Cardiovascular Health Trial.American journal of public health · 2020Article
- Is Moderate Drinking Protective Against Heart Disease? The Science, Politics and History of a Public Health Conundrum.The Milbank quarterly · 2020Article
- Alcohol and Dementia - What is the Link? A Systematic Review.Neuropsychiatric disease and treatment · 2020Review
- Daily Drinking Is Associated with Increased Mortality.Alcoholism, clinical and experimental research · 2018Article
- Alcohol Consumption, Hypertension, and Cardiovascular Health Across the Life Course: There Is No Such Thing as a One-Size-Fits-All Approach.Journal of the American Heart Association · 2018Article
- Risk thresholds for alcohol consumption: combined analysis of individual-participant data for 599 912 current drinkers in 83 prospective studies.Lancet (London, England) · 2018Article
- Cancers Attributable to Alcohol Consumption in Nigeria: 2012-2014.Frontiers in oncology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 9 institutions in 3 countries.
Funding
Abstract
Drinking within recommended limits is highly prevalent in much of the world, and strong epidemiological associations exist between moderate alcohol consumption and risk of several major chronic diseases, including coronary heart disease, diabetes, and breast cancer. In many cases, plausible biological mediators for these associations have been identified in randomized trials, but gold standard evidence that moderate drinking causes or prevents any chronic disease remains elusive and important concerns about available evidence have been raised. Although long-term randomized trials to test the observed associations have been termed impossible, clinical investigators have now successfully completed randomized trials of complex nutritional interventions in a variety of settings, along with trials of alcohol consumption itself of up to 2 years duration. The successful completion of these trials suggests that objections to the execution of a full-scale, long-term clinical trial of moderate drinking on chronic disease are increasingly untenable. We present potential lessons learned for such a trial and discuss key features to maximize its feasibility and value.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.