Evidence map›Paper›PMID 27687913›Full record

ArticleJournal of translational medicine2016

IL-27 attenuates airway inflammation in a mouse asthma model via the STAT1 and GADD45γ/p38 MAPK pathways.

Xiaoqiong Su, Jue Pan, Fengxi Bai, Honglei Yuan, Nian Dong, Dandan Li, Xiangdong Wang, Zhihong Chen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of translational medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
  2. Article
  3. Recent Insights Into Targeting Interleukin-27 in Coronary Artery Disease.Journal of cardiovascular translational research · 2025
    Review
  4. Article
  5. Article
  6. Article
  7. IL-30Experimental & molecular medicine · 2021
    Review
  8. Article
  9. Article
  10. Acupuncture Regulates the Balance of CD4Chinese journal of integrative medicine · 2019
    Article
  11. Article
  12. Article
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Xiaoqiong SuRespiratory Division of Zhongshan Hospital, Shanghai Institute of Respiratory Disease, Fudan University, No.180 Fenglin Road, Shanghai, China.
Jue PanRespiratory Division of Zhongshan Hospital, Shanghai Institute of Respiratory Disease, Fudan University, No.180 Fenglin Road, Shanghai, China.
Fengxi BaiRespiratory Division of Zhongshan Hospital, Shanghai Institute of Respiratory Disease, Fudan University, No.180 Fenglin Road, Shanghai, China.
Honglei YuanRespiratory Division of Zhongshan Hospital, Shanghai Institute of Respiratory Disease, Fudan University, No.180 Fenglin Road, Shanghai, China.
Nian DongRespiratory Division of Zhongshan Hospital, Shanghai Institute of Respiratory Disease, Fudan University, No.180 Fenglin Road, Shanghai, China.
Dandan LiRespiratory Division of Zhongshan Hospital, Shanghai Institute of Respiratory Disease, Fudan University, No.180 Fenglin Road, Shanghai, China.
Xiangdong WangRespiratory Division of Zhongshan Hospital, Shanghai Institute of Respiratory Disease, Fudan University, No.180 Fenglin Road, Shanghai, China. xiangdong.wang@clintransmed.org.
Zhihong ChenRespiratory Division of Zhongshan Hospital, Shanghai Institute of Respiratory Disease, Fudan University, No.180 Fenglin Road, Shanghai, China. czh60@hotmail.com.
Fudan University · CNZhongshan Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAsthma is prone to Th2-mediated chronic airway inflammation. Interleukin-27 (IL-27) is a member of the IL-12 family that promotes the differentiation of Th1 cells and inhibits Th2 cells. We use human/mouse CD4

methodsWe isolated and cultured CD4

resultsIn vitro, although IL-27 could inhibit naïve CD4

conclusionsPreventative administration of IL-27 improved the pathological changes in mouse asthma models via both the STAT1 and GADD45γ/p38 MAPK pathways while therapeutic administration of IL-27 had no significant effect, which may be due to the presence of already differentiated Th2 cells in asthmatic airways that resist IL-27 inhibition.

Indexed as

GADD45γIL-27p38 MAPKSTAT1Th2 development

Identifiers

PMID27687913
PMCPMC5041330
OpenAlexW2524087711

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.