Evidence map›Paper›PMID 27687784›Full record

ReviewMolecular nutrition & food research2017

Addressing the inter-individual variation in response to consumption of plant food bioactives: Towards a better understanding of their role in healthy aging and cardiometabolic risk reduction.

Claudine Manach, Dragan Milenkovic, Tom Van de Wiele, Ana Rodriguez-Mateos, Baukje de Roos, Maria Teresa Garcia-Conesa, Rikard Landberg, Eileen R Gibney, Marina Heinonen, Francisco Tomás-Barberán and 1 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Molecular nutrition & food research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
101citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

101 citing papers in PubMed, 7 syntheses or guidelines pooled it.

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41 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Claudine ManachINRA, UMR 1019, UNH, CRNH Auvergne, F-63000 Clermont-Ferrand; Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, BP 10448, F-63000, Clermont-Ferrand, France.
Dragan MilenkovicINRA, UMR 1019, UNH, CRNH Auvergne, F-63000 Clermont-Ferrand; Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, BP 10448, F-63000, Clermont-Ferrand, France.
Tom Van de WieleCenter for Microbial Ecology and Technology (CMET), Ghent University, Ghent, Belgium.
Ana Rodriguez-MateosDivision of Cardiology, Pulmonology and Vascular Medicine, Medical Faculty, University of Düsseldorf, Germany.
Baukje de RoosRowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen, UK.
Maria Teresa Garcia-ConesaResearch Group on Quality, Safety and Bioactivity of Plant Foods, CEBAS-CSIC, Campus de Espinardo, Murcia, Spain.
Rikard LandbergDepartment of Food Science, Swedish University of Agricultural Sciences, Uppsala, Sweden.
Eileen R GibneyUCD Institute of Food and Health, University College Dublin, Dublin, Republic of Ireland.
Marina HeinonenDepartment of Food and Environmental Sciences, Food Chemistry, University of Helsinki, Finland.
Francisco Tomás-BarberánResearch Group on Quality, Safety and Bioactivity of Plant Foods, CEBAS-CSIC, Campus de Espinardo, Murcia, Spain.
Christine MorandINRA, UMR 1019, UNH, CRNH Auvergne, F-63000 Clermont-Ferrand; Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, BP 10448, F-63000, Clermont-Ferrand, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bioactive compounds in plant-based foods have health properties that contribute to the prevention of age-related chronic diseases, particularly cardiometabolic disorders. Conclusive proof and understanding of these benefits in humans is essential in order to provide effective dietary recommendations but, so far, the evidence obtained from human intervention trials is limited and contradictory. This is partly due to differences between individuals in the absorption, distribution, metabolism and excretion of bioactive compounds, as well as to heterogeneity in their biological response regarding cardiometabolic health outcomes. Identifying the main factors underlying inter-individual differences, as well as developing new and innovative methodologies to account for such variability constitute an overarching goal to ultimately optimize the beneficial health effects of plant food bioactives for each and every one of us. In this respect, this position paper from the COST Action FA1403-POSITIVe examines the main factors likely to affect the individual responses to consumption of plant food bioactives and presents perspectives for assessment and consideration of inter-individual variability.

Indexed as

Healthy AgingCardiovascular DiseasesDietDiet, HealthyHealth BehaviorHumansMetabolic DiseasesPhytochemicalsPlants, EdibleRandomized Controlled Trials as TopicRisk FactorsRisk Reduction BehaviorPhytochemicalsBioavailability and metabolismBiological responsivenessCardiometabolic healthInter-individual variationPlant food bioactives

Identifiers

PMID27687784
PMCPMC5484307

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.