ArticleJournal of applied physiology (Bethesda, Md. : 1985)2016
Validity and reliability of measuring resting muscle sympathetic nerve activity using short sampling durations in healthy humans.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Ischemic preconditioning does not alter muscle sympathetic responses to static handgrip and metaboreflex activation in young healthy men.Physiological reports · 2017Trial
- Acute intermittent hypercapnic hypoxia augments left ventricular contractility.The Journal of physiology · 2026Article
- Sympathetic and blood pressure reactivity in young adults with major depressive disorder.Journal of affective disorders · 2024Article
- Reduced Stroke Volume and Brain Perfusion Drive Postural Hyperventilation in Postural Orthostatic Tachycardia Syndrome.JACC. Basic to translational science · 2024Article
- An open computational toolbox to analyze multi- and single-unit sympathetic nerve activity in microneurography.Biophysics reviews · 2024Article
- Impact of sampling duration on spontaneous sympathetic transduction.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2022Article
- Aortic haemodynamics: the effects of habitual endurance exercise, age and muscle sympathetic vasomotor outflow in healthy men.European journal of applied physiology · 2022Article
- Article
- Reproducibility of the neurocardiovascular responses to common laboratory-based sympathoexcitatory stimuli in young adults.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- Muscle sympathetic single-unit response patterns during progressive muscle metaboreflex activation in young healthy adults.Journal of neurophysiology · 2020Article
- Neural control of blood pressure is altered following isolated leg heating in aged humans.American journal of physiology. Heart and circulatory physiology · 2020Article
- Effects of dynamic arm and leg exercise on muscle sympathetic nerve activity and vascular conductance in the inactive leg.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Article
- Altered baroreflex sensitivity in young women with a family history of hypertension.Journal of neurophysiology · 2019Article
- Functional-Optical Coherence Tomography: A Non-invasive Approach to Assess the Sympathetic Nervous System and Intrinsic Vascular Regulation.Frontiers in physiology · 2019Article
- Evidence for Pressure-Independent Sympathetic Modulation of Central Pulse Wave Velocity.Journal of the American Heart Association · 2018Article
- The Stability and Repeatability of Spontaneous Sympathetic Baroreflex Sensitivity in Healthy Young Individuals.Frontiers in neuroscience · 2018Article
- Interindividual variability in muscle sympathetic responses to static handgrip in young men: evidence for sympathetic responder types?American journal of physiology. Regulatory, integrative and comparative physiology · 2018Article
- Muscle sympathetic nerve responses to passive and active one-legged cycling: insights into the contributions of central command.American journal of physiology. Heart and circulatory physiology · 2018Article
- Rapid onset pressor response to exercise in young women with a family history of hypertension.Experimental physiology · 2017Article
- Plasma hyperosmolality improves tolerance to combined heat stress and central hypovolemia in humans.American journal of physiology. Regulatory, integrative and comparative physiology · 2017Article
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7 authors.
Funding
Abstract
Resting muscle sympathetic nerve activity (MSNA) demonstrates high intraindividual reproducibility when sampled over 5-30 min epochs, although shorter sampling durations are commonly used before and during a stress to quantify sympathetic responsiveness. The purpose of the present study was to examine the intratest validity and reliability of MSNA sampled over 2 and 1 min and 30 and 15 s epoch durations. We retrospectively analyzed 68 resting fibular nerve microneurographic recordings obtained from 53 young, healthy participants (37 men; 23 ± 6 yr of age). From a stable 7-min resting baseline, MSNA (burst frequency and incidence, normalized mean burst amplitude, total burst area) was compared among each epoch duration and a standard 5-min control. Bland-Altman plots were used to determine agreement and bias. Three sequential MSNA measurements were collected using each sampling duration to calculate absolute and relative reliability (coefficients of variation and intraclass correlation coefficients). MSNA values were similar among each sampling duration and the 5-min control (all P > 0.05), highly correlated (r = 0.69-0.93; all P < 0.001), and demonstrated no evidence of fixed bias (all P > 0.05). A consistent proportional bias (P < 0.05) was present for MSNA burst frequency (all sampling durations) and incidence (1 min and 30 and 15 s), such that participants with low and high average MSNA underestimated and overestimated the true value, respectively. Reliability decreased progressively using the 30- and 15-s sampling durations. In conclusion, short 2 and 1 min and 30 s sampling durations can provide valid and reliable measures of MSNA, although increased sample size may be required for epochs ≤30 s, due to poorer reliability.
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