ReviewMolecular biology of the cell2016
Integrins as architects of cell behavior.
Review in Molecular biology of the cell, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 51 citations in OpenAlex.
- The Interplay Between Circadian Clocks and the Tumour Microenvironment in Breast Cancer.Cancers · 2026Review
- Integrin and Its Associated Proteins as a Mediator for Mechano-Signal Transduction.Biomolecules · 2025Review
- Collagen signaling and matrix stiffness regulate multipotency in glandular epithelial stem cells in mice.Nature communications · 2024Article
- Alpha-6 integrin deletion delays the formation of Brca1/p53-deficient basal-like breast tumors by restricting luminal progenitor cell expansion.Breast cancer research : BCR · 2024Article
- Development of circadian neurovascular function and its implications.Frontiers in neuroscience · 2023Review
- Two Distinct Mechanisms Underlying γδ T Cell-Mediated Regulation of Collagen Type I in Lung Fibroblasts.Cells · 2022Article
- SERPINA3C ameliorates adipose tissue inflammation through the Cathepsin G/Integrin/AKT pathway.Molecular metabolism · 2022Article
- Exposure to Bacteriophages T4 and M13 Increases Integrin Gene Expression and Impairs Migration of Human PC-3 Prostate Cancer Cells.Antibiotics (Basel, Switzerland) · 2021Article
- Article
- Transgenic overexpression of ITGB6 in intestinal epithelial cells exacerbates dextran sulfate sodium-induced colitis in mice.Journal of cellular and molecular medicine · 2021Article
- Evaluation of NanotargetedInternational journal of molecular sciences · 2021Article
- A role for the alpha-8 integrin chain (itga8) in glomerular homeostasis of the kidney.Molecular and cellular pediatrics · 2020Review
- Surface modification of polymeric electrospun scaffolds via a potent and high-affinity integrin α4β1 ligand improved the adhesion, spreading and survival of human chorionic villus-derived mesenchymal stem cells: a new insight for fetal tissue engineering.Journal of materials chemistry. B · 2020Article
- Vinculins interaction with talin is essential for mammary epithelial differentiation.Scientific reports · 2019Article
- Translating the matrix.British journal of pharmacology · 2019Article
- Integrin-Rac signalling for mammary epithelial stem cell self-renewal.Breast cancer research : BCR · 2018Article
- Disrupted circadian clocks and altered tissue mechanics in primary human breast tumours.Breast cancer research : BCR · 2018Article
- Group B streptococcus exploits vaginal epithelial exfoliation for ascending infection.The Journal of clinical investigation · 2018Article
- Extracellular matrix internalization links nutrient signalling to invasive migration.International journal of experimental pathology · 2018Review
- Tuning RGD Motif and Hyaluronan Density to Study Integrin Binding.Frontiers in physiology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Integrins are cell surface receptors that bind cells to their physical external environment, linking the extracellular matrix to cell function. They are essential in the biology of all animals. In the late 1980s, we discovered that integrins are required for the ability of breast epithelia to do what they are programmed to do, which is to differentiate and make milk. Since then, integrins have been shown to control most other aspects of phenotype: to stay alive, to divide, and to move about. Integrins also provide part of the mechanism that allows cells to form tissues. Here I discuss how we discovered that integrins control mammary gland differentiation and explore the role of integrins as central architects of other aspects of cell behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.