ArticleJournal of ovarian research2016
L-DOPA in the hu man ovarian follicular fluid acts as an antioxidant factor on granulosa cells.
Article in Journal of ovarian research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 8 citations in OpenAlex.
- Lauric acid and levodopa attenuate manganese-induced ovarian toxicity in balb/c mice via antioxidative, anti-inflammatory, and steroidogenic pathways.Journal of ovarian research · 2025Article
- A rapid and robust method for the cryopreservation of human granulosa cells.Histochemistry and cell biology · 2021Article
- A Role for HAntioxidants (Basel, Switzerland) · 2019Article
- The NADPH oxidase 4 is a major source of hydrogen peroxide in human granulosa-lutein and granulosa tumor cells.Scientific reports · 2019Article
- Human Luteinized Granulosa Cells-A Cellular Model for the Human Corpus Luteum.Frontiers in endocrinology · 2019Review
- Dopamine synthesis and dopamine receptor expression are disturbed in recurrent miscarriages.Endocrine connections · 2018Article
- Advanced oxidation protein products from the follicular microenvironment and their role in infertile women with endometriosis.Experimental and therapeutic medicine · 2018Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA previous study showed that dopamine (DA), which is contained in follicular fluid (FF) from IVF patients, strongly increased the production of reactive oxygen species (ROS) by cultured human granulosa cells (GCs). ROS, including H
resultsELISA measurements revealed that human IVF-derived FF contains L-DOPA. In cultured human GCs automated confluence analyses showed that L-DOPA enhanced their survival. This is in contrast to the actions of DA, which reduced cell survival. A dose-dependent mode of action of L-DOPA was identified using a fluorescent ROS indicator. The results showed that it antagonized intracellular ROS accumulation induced by exogenous H
conclusionsL-DOPA in FF is an antioxidant factor and exerts positive influences on GCs. Ovarian DA is derived from L-DOPA and has opposite actions. Exogenous L-DOPA is a standard therapy for Parkinson's disease, and the results raise the possibility that it may be able to exert positive actions as an antioxidant in ovarian conditions, as well.
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