ArticleNature communications2016
SCOP/PHLPP1β mediates circadian regulation of long-term recognition memory.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 59 citations in OpenAlex.
- Circadian rhythm disruption alters rhythmic properties of clock and memory gene expression in the hippocampi of rats.bioRxiv : the preprint server for biology · 2026Article
- Cellular- and systems-level profiling of amyloid-beta effects on circadian timing.Neurobiology of disease · 2026Article
- Predicting Performance in Working Memory During the Waking Period by Applying a Convolutional Neural Network to EEG Data in the N-Back Task: A Pilot Study.Sensors (Basel, Switzerland) · 2026Article
- Cellular- and systems-level profiling of amyloid-beta effects on circadian timing.bioRxiv : the preprint server for biology · 2025Article
- A Pocket Guide for the Experimenter Studying Daily Rhythms in Memory-Related Behavior.Current protocols · 2025Article
- mPFC DCC coupling with CaMKIITranslational psychiatry · 2025Article
- Circadian neurogenetics and its implications in neurophysiology, behavior, and chronomedicine.Neuroscience and biobehavioral reviews · 2024Review
- The clock gene Per1 is necessary in the retrosplenial cortex-but not in the suprachiasmatic nucleus-for incidental learning in young and aging male mice.Neurobiology of aging · 2023Article
- The circadian clock in the piriform cortex intrinsically tunes daily changes of odor-evoked neural activity.Communications biology · 2023Article
- Diurnal variation in declarative memory and the involvement of SCOP in cognitive functions in nonhuman primates.Molecular brain · 2023Article
- Control of complex behavior by astrocytes and microglia.Neuroscience and biobehavioral reviews · 2022Review
- Circadian disruption of hippocampus in an early senescence male mouse model.Pharmacology, biochemistry, and behavior · 2022Article
- Circadian clocks, cognition, and Alzheimer's disease: synaptic mechanisms, signaling effectors, and chronotherapeutics.Molecular neurodegeneration · 2022Review
- The Effects of Light and the Circadian System on Rhythmic Brain Function.International journal of molecular sciences · 2022Review
- Polysaccharides fromOxidative medicine and cellular longevity · 2022Article
- Impaired Morris water task retention following T21 light dark cycle exposure is not due to reduced hippocampal c-FOS expression.Frontiers in behavioral neuroscience · 2022Article
- Circadian rhythms as modulators of brain health during development and throughout aging.Frontiers in neural circuits · 2022Review
- Chronic circadian phase advance in male mice induces depressive-like responses and suppresses neuroimmune activation.Brain, behavior, & immunity - health · 2021Article
- Dysregulated clock gene expression and abnormal diurnal regulation of hippocampal inhibitory transmission and spatial memory in amyloid precursor protein transgenic mice.Neurobiology of disease · 2021Article
- The role of clock genes in sleep, stress and memory.Biochemical pharmacology · 2021Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Learning and memory depend on the time of day in various organisms, but it is not clear whether and how the circadian clock regulates memory performance. Here we show that consolidation of long-term recognition memory is a circadian-regulated process, which is blunted by disruption of the hippocampal clock. We focused on SCOP, a key molecule regulating hippocampus-dependent long-term memory for objects. The amounts of SCOP and its binding partner K-Ras in the hippocampal membrane rafts exhibit robust circadian changes, and SCOP knockdown in the hippocampal CA1 impairs long-term memory at night. Circadian changes in stimulus-dependent activation of ERK in the hippocampal neurons are dependent on the SCOP levels in the membrane rafts, while Scop knockout abrogates the activation rhythm. We conclude that long-term memory formation is regulated by the circadian clock through SCOP dynamics in the membrane rafts of the hippocampal CA1.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.