SynthesisInternational journal of obesity (2005)2016
Renal cell carcinoma survival and body mass index: a dose-response meta-analysis reveals another potential paradox within a paradox.
Synthesis in International journal of obesity (2005), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Adiposity and cancer survival: a systematic review and meta-analysis.Cancer causes & control : CCC · 2022Pooled it
- Association of Obesity With Survival Outcomes in Patients With Cancer: A Systematic Review and Meta-analysis.JAMA network open · 2021Pooled it
- Associating the risk of three urinary cancers with obesity and overweight: an overview with evidence mapping of systematic reviews.Systematic reviews · 2021Pooled it
- Muscle Mass Is a Better Predictor of Survival in Dogs With Chronic Kidney Disease Compared to Body Condition Score.Journal of animal physiology and animal nutrition · 2026Article
- Muscle matters: Skeletal muscle index and body mass index impact on complications and survival in renal cancer.BJUI compass · 2024Article
- Cardiorespiratory fitness and BMI measured in youth and 5-year mortality after site-specific cancer diagnoses in men-A population-based cohort study with register linkage.Cancer medicine · 2023Article
- The m6A modification-mediated OGDHL exerts a tumor suppressor role in ccRCC by downregulating FASN to inhibit lipid synthesis and ERK signaling.Cell death & disease · 2023Article
- Metabolic Dysregulation Explains the Diverse Impacts of Obesity in Males and Females with Gastrointestinal Cancers.International journal of molecular sciences · 2023Article
- Association of Body Mass Index With Outcomes Among Patients With Head and Neck Cancer Treated With Chemoradiotherapy.JAMA network open · 2023Observational
- Heterogeneity of Hippo signalling activity in different histopathologic subtypes of renal cell carcinoma.Journal of cellular and molecular medicine · 2023Article
- Exploring the Relationship between Obesity, Metabolic Syndrome and Neuroendocrine Neoplasms.Metabolites · 2022Review
- A hint for the obesity paradox and the link between obesity, perirenal adipose tissue and Renal Cell Carcinoma progression.Scientific reports · 2022Article
- A Clinical Decision Aid to Support Personalized Treatment Selection for Patients with Clinical T1 Renal Masses: Results from a Multi-institutional Competing-risks Analysis.European urology · 2022Article
- The Obesity Paradox Predicts the Second Wave of COVID-19 to Be Severe in Western Countries.International journal of environmental research and public health · 2021Article
- Body mass index as an independent risk factor for inferior vena cava resection during thrombectomy for venous tumor thrombus of renal cell carcinoma.World journal of surgical oncology · 2019Article
- The influence of sex on the prognostic value of body mass index in non-metastasis renal cell carcinoma.Cancer management and research · 2019Article
- The Plausibility of Obesity Paradox in Cancer-Point.Cancer research · 2018Review
- Association of body mass index with mortality and postoperative survival in renal cell cancer patients, a meta-analysis.Oncotarget · 2018Article
- Obesity as defined by waist circumference but not body mass index is associated with higher renal mass complexity.Urologic oncology · 2017Article
- The 'obesity paradox' may not be a paradox at all.International journal of obesity (2005) · 2017Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn healthy subjects increasing body mass index (BMI) leads to greater mortality from a range of causes. Following onset of specific diseases, however, the reverse is often found: called the 'obesity paradox'. But we recently observed the phenomenon called the 'paradox within the paradox' for stroke patients.
objectiveThe objective of our study was to examine the effect of each unit increase in BMI on renal cancer-specific survival (CSS), cancer-specific mortality, overall survival (OS) and overall mortality.
designRandom-effects generalized least squares models for trend estimation were used to analyze the data. Eight studies, comprising of 8699 survivals of 10 512 renal cell carcinoma (RCC) patients met the inclusion criteria, including 5 on CSS and 3 on OS.
resultsThe association of BMI with CSS and OS was non-linear (P<0.0001, P=0.004, respectively). We observed that CSS increased in relation to BMI, indicating that there was the obesity paradox in RCC. However, each unit increase in BMI over 25 was associated with decreased OS, indicating that RCC may also exhibit a paradox within the paradox.
conclusionsInconsistent effects of increases in BMI on CSS and OS, as previously observed for stroke, creates a paradox (different directions of mortality for different causes) within the obesity paradox.
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