Evidence map›Paper›PMID 27686406›Full record

ArticleHuman vaccines & immunotherapeutics2017

Inhibitory mechanism of peptides with a repeating hydrophobic and hydrophilic residue pattern on interleukin-10.

Guoying Ni, Yuejian Wang, Scott Cummins, Shelley Walton, Kate Mounsey, Xiaosong Liu, Ming Q Wei, Tianfang Wang

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human vaccines & immunotherapeutics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Genital warts treatment: Beyond imiquimod.Human vaccines & immunotherapeutics · 2018
    Review
  6. Recent Developments and Applications of the MMPBSA Method.Frontiers in molecular biosciences · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Guoying Nia Genecology Research Centre , University of the Sunshine Coast , Maroochydore , DC , Australia.
Yuejian Wangc Cancer Research Institute, Foshan First People's Hospital , Foshan , Guangdong , China.
Scott Cumminsa Genecology Research Centre , University of the Sunshine Coast , Maroochydore , DC , Australia.
Shelley Waltond Inflammation and Healing Research Cluster, School of Health and Sport Sciences , University of Sunshine Coast , Maroochydore , DC , Australia.
Kate Mounseyd Inflammation and Healing Research Cluster, School of Health and Sport Sciences , University of Sunshine Coast , Maroochydore , DC , Australia.
Xiaosong Liuc Cancer Research Institute, Foshan First People's Hospital , Foshan , Guangdong , China.
Ming Q Weib School of Medical Science, Griffith Health Institute , Griffith University , Gold Coast , Australia.
Tianfang Wanga Genecology Research Centre , University of the Sunshine Coast , Maroochydore , DC , Australia.
University of the Sunshine Coast · AUFirst People's Hospital of Foshan · CNGriffith University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Interleukin 10 (IL-10) is a cytokine that is able to downregulate inflammation. Its overexpression is directly associated with the difficulty in the clearance of chronic viral infections, such as chronic hepatitis B, hepatitis C and HIV infection, and infection-related cancer. IL-10 signaling blockade has been proposed as a promising way of clearing chronic viral infection and preventing tumor growth in animal models. Recently, we have reported that peptides with a helical repeating pattern of hydrophobic and hydrophilic residues are able to inhibit IL-10 significantly both in vitro and in vivo.

Indexed as

Cell LineCircular DichroismHumansImmunologic FactorsInterleukin-10Molecular Dynamics SimulationPeptidesSurface Plasmon ResonanceImmunologic FactorsInterleukin-10Peptidescircular dichroism spectroscopyELISAinterleukin-10 inhibiting peptideinterleukin-10 receptormolecular dynamic simulationsurface plasmon resonance spectroscopy

Identifiers

PMID27686406
PMCPMC5360125
OpenAlexW2526390665

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.