ArticleBMC biology2016
Insect odorant receptor trafficking requires calmodulin.
Article in BMC biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Lipid Metabolism in Relation to Calcium Homeostasis.Advances in experimental medicine and biology · 2026Review
- Review of the effects of two major plastic compounds in arthropods: a call for increased interdisciplinarity and further studies at the population level.Environmental science and pollution research international · 2025Review
- Volatile Organic Compounds in Biological Matrices as a Sensitive Weapon in Cancer Diagnosis.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Modulation of the NO-cGMP pathway has no effect on olfactory responses in theFrontiers in cellular neuroscience · 2023Article
- Patterns of Population Structure and Introgression Among Recently Differentiated Drosophila melanogaster Populations.Molecular biology and evolution · 2022Article
- Review
- Review
- Molecular characterization and expression variation of the odorant receptor co-receptor in the Formosan subterranean termite.PloS one · 2022Article
- Planthopper-Secreted Salivary Calmodulin Acts as an Effector for Defense Responses in Rice.Frontiers in plant science · 2022Article
- A Comparative Perspective on Functionally-Related, Intracellular Calcium Channels: The Insect Ryanodine and Inositol 1,4,5-Trisphosphate Receptors.Biomolecules · 2021Review
- Calmodulin regulates the olfactory performance in Drosophila melanogaster.Scientific reports · 2021Article
- Odor response adaptation in Drosophila-a continuous individualization process.Cell and tissue research · 2021Article
- A putative origin of the insect chemosensory receptor superfamily in the last common eukaryotic ancestor.eLife · 2020Article
- Molecular mechanisms of olfactory detection in insects: beyond receptors.Open biology · 2020Article
- Mass Spectrometry-Based Screening Platform Reveals Orco Interactome inMolecules and cells · 2018Article
- Access to the odor world: olfactory receptors and their role for signal transduction in insects.Cellular and molecular life sciences : CMLS · 2018Review
- Odorant Receptors and Odorant-Binding Proteins as Insect Pest Control Targets: A Comparative Analysis.Frontiers in physiology · 2018Review
- The Two Main Olfactory Receptor Families inFrontiers in cellular neuroscience · 2018Review
- Tuning Insect Odorant Receptors.Frontiers in cellular neuroscience · 2018Article
- Expression differences inPeerJ · 2017Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLike most animals, insects rely on their olfactory systems for finding food and mates and in avoiding noxious chemicals and predators. Most insect olfactory neurons express an odorant-specific odorant receptor (OR) along with Orco, the olfactory co-receptor. Orco binds ORs and permits their trafficking to the dendrites of antennal olfactory sensory neurons (OSNs), where together, they are suggested to form heteromeric ligand-gated non-selective cation channels. While most amino acid residues in Orco are well conserved across insect orders, one especially well-conserved region in Orco's second intracellular loop is a putative calmodulin (CaM) binding site (CBS). In this study, we explore the relationship between Orco and CaM in vivo in the olfactory neurons of Drosophila melanogaster.
resultsWe first found OSN-specific knock-down of CaM at the onset of OSN development disrupts the spontaneous firing of OSNs and reduces Orco trafficking to the ciliated dendrites of OSNs without affecting their morphology. We then generated a series of Orco CBS mutant proteins and found that none of them rescue the Orco-null Orco
conclusionsIn this study, we show CaM regulates OR trafficking and olfactory responses in vivo in Drosophila olfactory neurons via a well-conserved binding site on the olfactory co-receptor Orco. As CaM's modulation of Orco seems to be dependent on activity, we propose a model in which the CaM/Orco interaction allows insect OSNs to maintain appropriate dendritic levels of OR regardless of environmental odorant concentrations.
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