ArticleScientific reports2016
Genomic Regions Associated With Interspecies Communication in Dogs Contain Genes Related to Human Social Disorders.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 58 citations in OpenAlex.
- Inference of Autism Risk Genes Through Comparative Sociogenomics and Molecular Network Analysis.Genes · 2026Article
- Genetic testing predicts appearance but not behavior in dogs.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Reduced attention to human eyes in autism-associated Shank3 mutant laboratory beagle dogs.Molecular psychiatry · 2025Article
- After all, how valuable is the dog model for examining human socio-cognitive abilities?Biologia futura · 2025Review
- Genomic analysis of firework fear and noise reactivity in standard poodles.Canine medicine and genetics · 2023Article
- Personality traits associate with behavioral problems in pet dogs.Translational psychiatry · 2022Article
- Genetic testing of dogs predicts problem behaviors in clinical and nonclinical samples.BMC genomics · 2022Article
- Association of DNA methylation with energy and fear-related behaviors in canines.Frontiers in psychology · 2022Article
- A review of the unsolvable task in dog communication and cognition: comparing different methodologies.Animal cognition · 2021Review
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- Article
- A novel genomic region on chromosome 11 associated with fearfulness in dogs.Translational psychiatry · 2020Article
- Changed Patterns of Genomic Variation Following Recent Domestication: Selection Sweeps in Farmed Atlantic Salmon.Frontiers in genetics · 2020Article
- Maladaptation in feral and domesticated animals.Evolutionary applications · 2019Review
- Two novel genomic regions associated with fearfulness in dogs overlap human neuropsychiatric loci.Translational psychiatry · 2019Article
- Domesticated dogs (Canis familiaris) tend to follow repeated deceptive human cues even when food is visible.Learning & behavior · 2018Article
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- Genetics and Genomics of Social Behavior in a Chicken Model.Genetics · 2018Article
- Sociability modifies dogs' sensitivity to biological motion of different social relevance.Animal cognition · 2018Article
- Sociality genes are associated with human-directed social behaviour in golden and Labrador retriever dogs.PeerJ · 2018Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Unlike their wolf ancestors, dogs have unique social skills for communicating and cooperating with humans. Previously, significant heritabilities for human-directed social behaviors have been found in laboratory beagles. Here, a Genome-Wide Association Study identified two genomic regions associated with dog's human-directed social behaviors. We recorded the propensity of laboratory beagles, bred, kept and handled under standardized conditions, to initiate physical interactions with a human during an unsolvable problem-task, and 190 individuals were genotyped with an HD Canine SNP-chip. One genetic marker on chromosome 26 within the SEZ6L gene was significantly associated with time spent close to, and in physical contact with, the human. Two suggestive markers on chromosome 26, located within the ARVCF gene, were also associated with human contact seeking. Strikingly, four additional genes present in the same linkage blocks affect social abilities in humans, e.g., SEZ6L has been associated with autism and COMT affects aggression in adolescents with ADHD. This is, to our knowledge, the first genome-wide study presenting candidate genomic regions for dog sociability and inter-species communication. These results advance our understanding of dog domestication and raise the use of the dog as a novel model system for human social disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.