ArticleThe American journal of surgical pathology2017
Mesenteric Tumor Deposits in Midgut Small Intestinal Neuroendocrine Tumors Are a Stronger Indicator Than Lymph Node Metastasis for Liver Metastasis and Poor Prognosis.
Article in The American journal of surgical pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Impact of Sex and Deprivation on Neuroendocrine Tumour Survival: Challenges of Heterogeneous Data.Neuroendocrinology · 2025Pooled it
- Tumor size and vascular and perineural invasion predict mesenteric involvement in small-intestinal neuroendocrine tumors.Endocrine · 2026Article
- Surgical management of small intestinal neuroendocrine tumours.The British journal of surgery · 2026Article
- Oncological Outcomes after Elective and Emergency Resection of Small Intestinal Neuroendocrine Tumours.Journal of gastrointestinal cancer · 2026Observational
- Review
- Article
- Aggressiveness in Well-Differentiated Small Intestinal Neuroendocrine Tumors: A Rare Case and Narrative Literature Review.Journal of clinical medicine · 2025Review
- Surgical planning of small intestine neuroendocrine tumors: the concept of mesenteric tumor deposits.Endocrine oncology (Bristol, England) · 2025Article
- Predicting tumor deposits in rectal cancer: a combined deep learning model using T2-MR imaging and clinical features.Insights into imaging · 2023Article
- Management of Small Bowel Neuroendocrine Tumours: 10 Years' Experience at a Tertiary Referral Centre.Cancers · 2023Article
- Early Definitive Diagnosis and Management of Incidental Neuroendocrine Tumors Found on Gastrointestinal Endoscopy.Cureus · 2023Article
- Reappraisal of Tumor Deposit as a Prognostic Factor in Pancreatic Cancer.Annals of surgical oncology · 2023Article
- ASO Author Reflections: Prognostic Value of Tumor Deposits in Resected Pancreatic Ductal Adenocarcinoma.Annals of surgical oncology · 2023Article
- Association of tumor deposits with tumor-infiltrating lymphocytes and prognosis in gastric cancer.World journal of surgical oncology · 2022Article
- Survival effects of primary and metastatic surgical treatment in metastatic small intestinal tumors: A propensity score-matching study.PloS one · 2022Article
- Ileal Neuroendocrine Tumor in a Patient with Sclerosing Mesenteritis: Which Came First?The American journal of case reports · 2021Article
- Impact of Peritoneal Metastasis on Survival of Patients With Small Intestinal Neuroendocrine Tumor.The American journal of surgical pathology · 2019Article
- Peritoneal Carcinomatosis in Well-Differentiated Small-Intestinal Neuroendocrine Tumors with Mesenteric Tumor Deposits.Journal of medical & surgical pathology · 2019Article
- Mesenteric tumour deposits arising from small-intestine neuroendocrine tumours are frequently associated with fibrosis and IgG4-expressing plasma cells.Histopathology · 2018Article
- Number, not size, of mesenteric tumor deposits affects prognosis of small intestinal well-differentiated neuroendocrine tumors.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2018Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Mesenteric tumor deposits (MTDs) are not included in the American Joint Committee on Cancer (AJCC) staging system for midgut small intestinal neuroendocrine tumors (NETs). We examined the prognostic significance of MTDs associated with midgut NETs. Hematoxylin and eosin slides from 132 resected jejunal/ileal NETs were reviewed for AJCC tumor stage, lymph node (LN) metastasis, MTDs, and hepatic metastases. MTDs were defined as discrete irregular mesenteric tumor nodules discontinuous from the primary tumor. Clinical or pathologic evidence of metastases and survival data were abstracted from electronic medical records. The cohort included 72 male and 60 female patients with a median age of 60 years. LN metastasis, MTDs, and liver metastasis were present in 80%, 68%, and 58% of patients, respectively. Female sex and presence of MTDs were independent predictors of liver metastasis. The odds ratio for hepatic metastasis in the presence of MTDs was 16.68 (95% confidence interval [CI], 4.66-59.73) and 0.81 (95% CI, 0.20-3.26) for LN metastasis. Age, MTDs, and hepatic metastasis were associated with disease-specific survival (DSS) in univariate analysis. Primary tumor histologic grade, pT3/T4 stage, and LN metastasis were not associated with DSS. Multivariate analysis of liver metastasis-free survival stratified by tumor grade showed that MTDs were associated with adverse outcomes. The hazard ratio for MTDs was 4.58 (95% CI, 1.89-11.11), compared with 0.98 (95% CI, 0.47-2.05) for LN metastasis. MTDs, but not LN metastasis, in midgut NETs are a strong predictor for hepatic metastasis and are associated with poor DSS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.