ArticleMedicine2016
Identification of benign and malignant thyroid nodules by in vivo iodine concentration measurement using single-source dual energy CT: A retrospective diagnostic accuracy study.
Article in Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 39 citations in OpenAlex.
- Prediction of thyroid function based on CT radiomics: a two-center study.Quantitative imaging in medicine and surgery · 2025Article
- Article
- Four-Dimensional Dual-Energy Computed Tomography-Derived Parameters and Their Correlation with Thyroid Gland Functional Status.Tomography (Ann Arbor, Mich.) · 2025Article
- The clinical significance and burden of thyroid nodules discovered incidentally.Irish journal of medical science · 2025Observational
- Clinical value of dual-energy CT for predicting occult metastasis in central neck lymph nodes of papillary thyroid carcinoma.European radiology · 2024Article
- Diagnostic accuracy of dual-energy computed tomography-based nomogram for differentiating papillary thyroid microcarcinomas from micronodular goiters.Quantitative imaging in medicine and surgery · 2023Article
- Nomogram based on spectral CT quantitative parameters and typical radiological features for distinguishing benign from malignant thyroid micro-nodules.Cancer imaging : the official publication of the International Cancer Imaging Society · 2023Article
- Application of spectral CT in diagnosis, classification and prognostic monitoring of gastrointestinal cancers: progress, limitations and prospects.Frontiers in molecular biosciences · 2023Review
- Gemstone Spectral CT Virtual Noncontrast Images and Iodine Maps for the Characterization of Thyroid Lesions and Distinguishing Thyroid Papillary Carcinoma from Nodular Goiter.International journal of endocrinology · 2023Article
- Differential diagnosis of thyroid nodule capsules using random forest guided selection of image features.Scientific reports · 2022Article
- Iodine Images in Dual-energy CT: Detection of Hepatic Steatosis by Quantitative Iodine Concentration Values.Journal of digital imaging · 2022Article
- Iodine Maps from Dual-Energy CT to Predict Extrathyroidal Extension and Recurrence in Papillary Thyroid Cancer Based on a Radiomics Approach.AJNR. American journal of neuroradiology · 2022Article
- Differentiating pulmonary metastasis from benign lung nodules in thyroid cancer patients using dual-energy CT parameters.European radiology · 2022Article
- Dual-source dual-energy computed tomography-derived quantitative parameters combined with machine learning for the differential diagnosis of benign and malignant thyroid nodules.Quantitative imaging in medicine and surgery · 2022Article
- Iodine images in dual energy CT: A monocentric study benchmarking quantitative iodine concentration values of the healthy liver.PloS one · 2022Article
- Dual energy CT in gland tumors: a comprehensive narrative review and differential diagnosis.Gland surgery · 2020Review
- How accurate and precise are CT based measurements of iodine concentration? A comparison of the minimum detectable concentration difference among single source and dual source dual energy CT in a phantom study.European radiology · 2019Article
- A case of mixed-pattern calcifications in multinodular goiter associated with a benign diagnosis.International journal of surgery case reports · 2019Article
- Comparative study of dual energy CT iodine imaging and standardized concentrations before and after chemoradiotherapy for esophageal cancer.BMC cancer · 2018Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study proposed to determine whether in vivo iodine concentration measurement by single-source dual energy (SSDE) CT can improve differentiation between benign and malignant thyroid nodules. In total, 53 patients presenting with thyroid nodules underwent SSDE CT scanning. Iodine concentrations were measured for each nodule and normal thyroid tissue using the GSI-viewer image analysis software. A total of 26 thyroid nodules were malignant in 26 patients and confirmed by surgery; 33 nodules from 27 patients were benign, with 10 confirmed by surgery and others after follow-up. Iodine concentrations with plain CT were significantly lower in malignant than benign nodules (0.47 ± 0.20 vs 1.17 ± 0.38 mg/mL, P = 0.00). Receiver operating characteristic (ROC) curve showed an area under the curve (AUC) of 0.93; with a cutoff of 0.67, iodine concentration showed 92.3% sensitivity and 88.5% specificity in diagnosing malignancy. Iodine concentration obtained by enhanced and plain CT were significantly higher in malignant than benign nodules (9.05 ± 3.35 vs 3.46 ± 2.24 mg/mL, P = 0.00). ROC curve analysis showed an AUC of 0.93; with a cutoff value of 3.37, iodine concentration displayed 78% sensitivity, 95% specificity in diagnosing malignancy. Combining unenhanced with enhanced iodine concentrations, the diagnostic equation was: Y = -8.641 × unenhanced iodine concentration + 0.663 × iodine concentration. ROC curve showed an AUC of 0.98 (95% CI, 0.94, 1.00). With Y ≥ -2 considered malignancy, diagnostic sensitivity and specificity were 96%, 96.3%, respectively. This study concluded that SSDE CT can detect the differences in iodine uptake and blood supply between benign and malignant thyroid lesions.
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