Evidence map›Paper›PMID 27684793›Full record

SynthesisMedicine2016

Association of genetic variants in the receptor for advanced glycation end products gene with diabetic retinopathy: A meta-analysis.

Weihong Yu, Jingyun Yang, Wenda Sui, Bin Qu, Ping Huang, Youxin Chen

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
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  4. Article
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  6. Observational
  7. Review
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Weihong YuaDepartment of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Science, Beijing, China bRush Alzheimer's Disease Center, Rush University Medical Center cDepartment of Neurological Sciences, Rush University Medical Center, Chicago, IL dDepartment of Ophthalmology, People's Hospital of Beijing Daxing District, Beijing eDepartment of Ophthalmology, Traditional Chinese Medicine Hospital of Muping District of Yantai City, Shandong, China.
Jingyun Yang
Wenda Sui
Bin Qu
Ping Huang
Youxin Chen

Funding

Exploring the Role of the Brain Epigenome: Cognitive Decline and Life ExperiencesR01AG036042 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2009 to 2013
$4.1M
NIA NIH HHS R01 AG036042
6 · The paper itself

Abstract

backgroundDiabetic retinopathy (DR) is a major sight-threatening diabetic complication. Previous studies have examined the association of DR with multiple genetic variants in the receptor for advanced glycation end products (RAGE) gene, with inconsistent results.

objectiveTo perform a systematic literature search and conduct meta-analyses to examine the association of genetic variants in RAGE with DR. DATA SOURCES: PubMed, Cochrane Library, Embase, Google Scholar, and HuGE. STUDY ELIGIBILITY CRITERIA AND

participantsStudies were on human subjects; the studies were case-control ones and included subjects who had DR and those who did not have DR; and the studies provided genotype data for genetic variants in RAGE, separately for subjects who had and did not have DR, or provided odds ratios (ORs) and the 95% confidence intervals (CIs), or provided sufficient data for the calculation of OR and the 95% CI. STUDY APPRAISAL AND SYNTHESIS

methodsWe used OR as a measure of association, and used random-effects model in all the meta-analyses. Between-study heterogeneity was assessed using I, and publication bias was evaluated using Egger test.

resultsA total of 13 studies met the eligibility criteria and were included in our analyses. We found that Gly82Ser was significantly associated with DR (OR = 2.40, 95% CI: 1.46-3.97; P = 0.001) using a recessive model. -374T/A also showed significant association with DR under a dominant model (OR = 1.21, 95% CI: 1.03-1.43; P = 0.023). We did not find a significant association of DR with other genetic variants in RAGE. LIMITATIONS: The number of included studies is small for some genetic variants; duration of diabetes varied across studies; most studies were conducted in Asia; and it is not clear whether the observed association can be generalized to other ethnicities; and we could not control for other potential confounding factors. CONCLUSIONS AND IMPLICATIONS OF KEY

findingsWe found that Gly82Ser in RAGE showed significant association with DR. More studies with larger sample sizes that control for important risk factors, such as duration of diabetes, are needed to validate our findings.

Indexed as

Case-Control StudiesDiabetic RetinopathyGenetic Predisposition to DiseaseGenetic VariationGenotypeHumansOdds RatioPolymorphism, Single NucleotideReceptor for Advanced Glycation End ProductsRisk FactorsAGER protein, humanReceptor for Advanced Glycation End Products

Identifiers

PMID27684793
PMCPMC5265886

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.