ArticleJournal of visualized experiments : JoVE2016
A Rat Carotid Balloon Injury Model to Test Anti-vascular Remodeling Therapeutics.
Article in Journal of visualized experiments : JoVE, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Surgical Rodent Models for the Study of Peripheral Arterial Disease.Biomedicines · 2026Review
- Osteocalcin deficiency attenuates neointima formation after vascular injury in rat.BMC cardiovascular disorders · 2025Article
- Isolation and focal treatment of brain aneurysms using interfacial fluid trapping.Science advances · 2024Article
- Sex differences in arterial identity correlate with neointimal hyperplasia after balloon injury.Molecular biology reports · 2022Article
- Investigation into the role of Stmn2 in vascular smooth muscle phenotype transformation during vascular injury via RNA sequencing and experimental validation.Environmental science and pollution research international · 2022Article
- Huotan Jiedu Tongluo Decoction Inhibits Balloon-Injury-Induced Carotid Artery Intimal Hyperplasia in the Rat through the PERK-eIF2Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Molecular Ultrasound Monitoring of Early Artery Injury After Carotid Balloon Angioplasty.Frontiers in pharmacology · 2018Article
Corrections and comments
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Authors and funding
6 authors.
Funding
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Abstract
The rat carotid balloon injury is a well-established surgical model that has been used to study arterial remodeling and vascular cell proliferation. It is also a valuable model system to test, and to evaluate therapeutics and drugs that negate maladaptive remodeling in the vessel. The injury, or barotrauma, in the vessel lumen caused by an inflated balloon via an inserted catheter induces subsequent neointimal growth, often leading to hyperplasia or thickening of the vessel wall that narrows, or obstructs the lumen. The method described here is sufficiently sensitive, and the results can be obtained in relatively short time (2 weeks after the surgery). The efficacy of the drug or therapeutic against the induced-remodeling can be evaluated either by the post-mortem pathological and histomorphological analysis, or by ultrasound sonography in live animals. In addition, this model system has also been used to determine the therapeutic window or the time course of the administered drug. These studies can leadto the development of a better administrative strategy and a better therapeutic outcome. The procedure described here provides a tool for translational studies that bring drug and therapeutic candidates from bench research to clinical applications.
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