Evidence map›Paper›PMID 27684429›Full record

ArticleAnnals of the American Thoracic Society2016

Respiratory Effects of Indoor Heat and the Interaction with Air Pollution in Chronic Obstructive Pulmonary Disease.

Meredith C McCormack, Andrew J Belli, Darryn Waugh, Elizabeth C Matsui, Roger D Peng, D'Ann L Williams, Laura Paulin, Anik Saha, Charles M Aloe, Gregory B Diette and 2 more

Abstract read
In one paragraph

Article in Annals of the American Thoracic Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. What's new in the 2025 GOLD report.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. Iron Deficiency and All-Cause Hospitalization Risk in a Clinical Cohort of COPD.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2025
    Article
  15. Observational
  16. SARS-CoV-2 and Environmental Changes: The Perfect Storm.Current issues in molecular biology · 2024
    Review
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Meredith C McCormack1 Department of Medicine, Division of Pulmonary and Critical Care, and.
Andrew J Belli1 Department of Medicine, Division of Pulmonary and Critical Care, and.
Darryn Waugh3 Department of Earth and Planetary Sciences, Johns Hopkins University, Baltimore, Maryland.
Elizabeth C Matsui4 Department of Pediatrics, Division of Allergy and Immunology, Johns Hopkins University School of Medicine.
Roger D Peng5 Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, and.
D'Ann L Williams2 Department of Environmental Health Sciences, and.
Laura Paulin1 Department of Medicine, Division of Pulmonary and Critical Care, and.
Anik Saha1 Department of Medicine, Division of Pulmonary and Critical Care, and.
Charles M Aloe4 Department of Pediatrics, Division of Allergy and Immunology, Johns Hopkins University School of Medicine.
Gregory B Diette1 Department of Medicine, Division of Pulmonary and Critical Care, and.
Patrick N Breysse2 Department of Environmental Health Sciences, and.
Nadia N Hansel1 Department of Medicine, Division of Pulmonary and Critical Care, and.

Funding

Oxidative Stress & Inflammation in a Human PM Nasal ChallengeP50ES015903 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI BREYSSE, PATRICK N · 2007 to 2011
$12.1M
The role of obesity in biological responses to particulate matter in miceP50ES018176 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI HANSEL, NADIA N · 2015 to 2019
$4.8M
Project 3: Dissecting the Diet Asthma Relationship in Mice Models of AsthmaP01ES018176 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI DIETTE, GREGORY B · 2009 to 2013
$4.2M
The Environmental Assessments Core (FSC)P50MD010431 · NIMHD · JOHNS HOPKINS UNIVERSITY · PI MATSUI, ELIZABETH C. · 2015 to 2019
$3.5M
Clinical trial of air cleaners to improve indoor air quality and COPD healthR01ES022607 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI HANSEL, NADIA N · 2013 to 2017
$3.4M
SPIROMICS - Air Pollution StudyR01ES023500 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI HANSEL, NADIA N, KAUFMAN, JOEL DANIEL · 2014 to 2018
$3.2M
Statistical Methods for Complex Enivronmental Health DataR01ES019560 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI PENG, ROGER · 2011 to 2015
$1.8M
Mentoring in Patient-Oriented Research on Asthma and the Indoor EnvironmentK24AI114769 · NIAID · UNIVERSITY OF TEXAS AT AUSTIN · PI MATSUI, ELIZABETH C. · 2015 to 2023
$1.6M
Indoor Air Pollution, Mucociliary Clearance, and Mucus Properties in COPDK23ES025781 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI PAULIN, LAURA MARIE · 2015 to 2019
$832k
Domestic endotoxin exposure and chronic obstructive pulmonary diseaseR21ES015781 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI HANSEL, NADIA N · 2008 to 2009
$451k
Clean Air- Heart: Clinical trial of an air purifier intervention to reduce indoor particulate matter and improve cardiovascular outcomes in COPDR21ES025840 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI MCCORMACK, MEREDITH C · 2015 to 2016
$446k
Health Effects of Extreme Heat among Vulnerable Populations with Asthma and COPDR21ES024021 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI MCCORMACK, MEREDITH C · 2013 to 2014
$443k
NIAID NIH HHS K24 AI114769NIEHS NIH HHS K23 ES025781NIEHS NIH HHS P01 ES018176NIEHS NIH HHS P50 ES015903NIEHS NIH HHS P50 ES018176NIEHS NIH HHS R01 ES019560NIEHS NIH HHS R01 ES022607NIEHS NIH HHS R01 ES023500NIEHS NIH HHS R21 ES015781NIEHS NIH HHS R21 ES024021NIEHS NIH HHS R21 ES025840NIMHD NIH HHS P50 MD010431
6 · The paper itself

Abstract

rationaleThere is limited evidence of the effect of exposure to heat on chronic obstructive pulmonary disease (COPD) morbidity, and the interactive effect between indoor heat and air pollution has not been established.

objectivesTo determine the effect of indoor and outdoor heat exposure on COPD morbidity and to determine whether air pollution concentrations modify the effect of temperature.

methodsSixty-nine participants with COPD were enrolled in a longitudinal cohort study, and data from the 601 participant days that occurred during the warm weather season were included in the analysis. Participants completed home environmental monitoring with measurement of temperature, relative humidity, and indoor air pollutants and simultaneous daily assessment of respiratory health with questionnaires and portable spirometry. MEASUREMENTS AND MAIN

resultsParticipants had moderate to severe COPD and spent the majority of their time indoors. Increases in maximal indoor temperature were associated with worsening of daily Breathlessness, Cough, and Sputum Scale scores and increases in rescue inhaler use. The effect was detected on the same day and lags of 1 and 2 days. The detrimental effect of temperature on these outcomes increased with higher concentrations of indoor fine particulate matter and nitrogen dioxide (P < 0.05 for interaction terms). On days during which participants went outdoors, increases in maximal daily outdoor temperature were associated with increases in Breathlessness, Cough, and Sputum Scale scores after adjusting for outdoor pollution concentrations.

conclusionsFor patients with COPD who spend the majority of their time indoors, indoor heat exposure during the warmer months represents a modifiable environmental exposure that may contribute to respiratory morbidity. In the context of climate change, adaptive strategies that include optimization of indoor environmental conditions are needed to protect this high-risk group from the adverse health effects of heat.

Indexed as

SeasonsAgedAir Pollution, IndoorClimate ChangeEnvironmental ExposureFemaleHome Care ServicesHot TemperatureHumansLongitudinal StudiesMaleMarylandMiddle AgedNitrogen DioxideParticulate MatterPulmonary Disease, Chronic ObstructiveNitrogen DioxideParticulate Matterchronic obstructive pulmonary diseaseclimate changeheatnitrogen dioxideparticulate matter

Identifiers

PMID27684429
PMCPMC5291496

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.