Trial reportJournal of perinatology : official journal of the California Perinatal Association2017
Oral colostrum priming shortens hospitalization without changing the immunomicrobial milieu.
Trial report in Journal of perinatology : official journal of the California Perinatal Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01776268 (Effect of Colostrum on Innate Mucosal Immunity in Very Premature Infants), which is not on this map. Cited by 23 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Colostrum on Innate Mucosal Immunity in Very Premature Infants
Who cites it
23 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Eligible Infants Included in Neonatal Clinical Trials and Reasons for Noninclusion: A Systematic Review.JAMA network open · 2024Pooled it
- Race and Ethnicity of Infants Enrolled in Neonatal Clinical Trials: A Systematic Review.JAMA network open · 2023Pooled it
- Intervention Effect of Oropharyngeal Administration of Colostrum in Preterm Infants: A Meta-Analysis.Frontiers in pediatrics · 2022Pooled it
- Oropharyngeal colostrum immunotherapy and nutrition in preterm newborns: meta-analysis.Revista de saude publica · 2021Pooled it
- Effects of oropharyngeal administration of colostrum on the incidence of necrotizing enterocolitis, late-onset sepsis, and death in preterm infants: a meta-analysis of RCTs.European journal of clinical nutrition · 2020Pooled it
- Oropharyngeal Colostrum for Preterm Infants: A Systematic Review and Meta-Analysis.Advances in nutrition (Bethesda, Md.) · 2019Pooled it
- Oropharyngeal colostrum in preventing mortality and morbidity in preterm infants.The Cochrane database of systematic reviews · 2018Pooled it
- Effects of oropharyngeal administration of own mother's milk on oral microbial colonization in very low birth weight infants fed by gastric tube: A randomized controlled trial.Immunity, inflammation and disease · 2024Trial
- A randomized controlled trial of oropharyngeal therapy with mother's own milk for premature infants.Journal of perinatology : official journal of the California Perinatal Association · 2023Trial
- Nutritional management at 22-23 weeks gestational age: evidence and knowledge gaps.Pediatric research · 2026Review
- Recent Advances in Antimicrobial Proteins and Peptides: A Promising Clinical Breakthrough and Patent Landscape.Current protein & peptide science · 2026Review
- Article
- Influence of oropharyngeal therapy with mother's own milk on the microbiome and metabolome of very preterm infants: a pilot study.Frontiers in nutrition · 2025Article
- A Scoping Review of the Oral Microbiome in Preterm Infants.American journal of perinatology · 2024Article
- Short-Term Outcomes of Early Oral Colostrum Administration in VLBW Neonates: An Open-Label Randomized Controlled Trial.Medical journal of the Islamic Republic of Iran · 2024Article
- Oropharyngeal administration of colostrum targeting gut microbiota and metabolites in very preterm infants: protocol for a multicenter randomized controlled trial.BMC pediatrics · 2023Article
- Review
- Oral Application of Mother's Own Milk for Reducing Necrotizing Enterocolitis in Preterm Infants: An Updated Meta-Analysis of RCTs.Evidence-based complementary and alternative medicine : eCAM · 2023Article
- Impact of Oropharyngeal Administration of Colostrum in Preterm Newborns' Oral Microbiome.Nutrients · 2021Observational
- Colostrum oropharyngeal immunotherapy for very low birth weight preterm infants: protocol of an intervention study.BMC pediatrics · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
objectiveOral colostrum priming (OCP) after birth in preterm infants is associated with improved weight gain and modification of the oral immunomicrobial environment. We hypothesized that OCP would modify salivary immune peptides and the oral microbiota in preterm infants. STUDY
designWe conducted a prospective, randomized clinical trial to determine the effects of OCP on salivary immune peptide representation in preterm infants (<32 weeks completed gestation at birth). Saliva samples were collected before and after OCP. Salivary immune peptide representation was determined via mass spectroscopy. Oral microbiota representation was determined via sequencing of the 16S rRNA gene.
resultsNeonates who received OCP (n=48) had a 16-day reduction in the median length of hospitalization as compared with infants who did not receive OCP (n=51). No differences in salivary immune peptide sequence representation before OCP between groups were found. Longitudinal changes in peptides were detected (lysozyme C, immunoglobulin A, lactoferrin) but were limited to a single peptide difference (α-defensin 1) between primed and unprimed infants after OCP. We found no difference in microbial diversity between treatment groups at any time point, but diversity decreased significantly over time in both groups. OCP treatment marginally modified oral taxa with a decline in abundance of Streptococci in the OCP group at 30 days of life.
conclusionsOCP had neither an effect on the salivary peptides we examined nor on overall oral bacterial diversity and composition. Infants who received OCP had a reduced length of hospitalization and warrants further investigation.
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