ArticleJournal of perinatology : official journal of the California Perinatal Association2017
Identification of bacterial invasion in necrotizing enterocolitis specimens using fluorescent in situ hybridization.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed.
- Maternal Nutritional Status and the Microbiome across the Pregnancy and the Post-Partum Period.Microorganisms · 2023Review
- Exploring the Role of Gut Bacteria in Health and Disease in Preterm Neonates.International journal of environmental research and public health · 2020Review
- Expressions of Fib, IL-12 in Serum of Neonatal Necrotizing Enterocolitis and Their Correlation with Clinicopathological Features.Iranian journal of public health · 2020Article
- The Role of Glycosaminoglycans in Protection from Neonatal Necrotizing Enterocolitis: A Narrative Review.Nutrients · 2020Review
- Molecular epidemiology ofNew microbes and new infections · 2019Article
- Regulation of ROS-NF-κB axis by tuna backbone derived peptide ameliorates inflammation in necrotizing enterocolitis.Journal of cellular physiology · 2019Article
- Multidisciplinary evaluation of Clostridium butyricum clonality isolated from preterm neonates with necrotizing enterocolitis in South France between 2009 and 2017.Scientific reports · 2019Article
- Nutritional strategies and gut microbiota composition as risk factors for necrotizing enterocolitis in very-preterm infants.The American journal of clinical nutrition · 2017Article
- Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveInvestigation of bacterial invasion into the intestinal wall in necrotizing enterocolitis (NEC) specimens. STUDY
designWe compared 43 surgical NEC specimens with 43 age-matched controls. We used fluorescent in situ hybridization (FISH), a universal bacterial probe together with species-specific probes for Clostridium spp., Enterobacteriaceae, bacteroides and enterococci/lactobacilli. We used a FISH scoring system to reveal invasion of the intestinal wall, in which 1 represented no colonies and 4 invasion of the intestinal wall.
resultsWe observed invasion of the intestinal wall in 22/43 of the most affected NEC tissue samples as compared with 16/43 in the least affected NEC tissue samples (P=0.03). A FISH score of 4 was reached in 7/43 control cases. Enterobacteriaceae dominated the NEC specimens. Clostridium spp. were detected occasionally in NEC samples.
conclusionBacterial invasion of the intestinal wall is more present in most affected NEC tissue samples compared with least affected NEC tissue samples or controls. Enterobacteriaceae are prevalent in advanced NEC.
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Registered trials
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