ArticleJournal of visualized experiments : JoVE2016
Murine Flexor Tendon Injury and Repair Surgery.
Article in Journal of visualized experiments : JoVE, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 44 citations in OpenAlex.
- Analysis of the Effects of Early Rehabilitation Treatment Conducted by Nurses on the Prevention of Tendon Adhesion after Finger Flexor Tendon Rupture: A Randomized Clinical Trial.International journal of clinical practice · 2022Trial
- Characterizing tendon microstructure using metrics associated with the angular dependence of ultrasound backscatter.The Journal of the Acoustical Society of America · 2026Article
- Comparative Analysis of Tendon Healing in a Clinically Relevant Mouse Model of Achilles Tendon Repair.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026Article
- Epitenon-derived progenitors drive fibrosis and regeneration after flexor tendon injury in a spatially-dependent manner.Nature communications · 2025Article
- Ogerin induced activation of Gpr68 alters tendon healing.FASEB bioAdvances · 2025Article
- Pharmacological antagonism of Ccr2+ cell recruitment to facilitate regenerative tendon healing.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025Article
- Loss ofMatrix biology plus · 2025Article
- Loss ofbioRxiv : the preprint server for biology · 2024Article
- Pharmacological Antagonism of Ccr2+ Cell Recruitment to Facilitate Regenerative Tendon Healing.bioRxiv : the preprint server for biology · 2024Article
- Identification of Periostin as a critical niche for myofibroblast dynamics and fibrosis during tendon healing.Matrix biology : journal of the International Society for Matrix Biology · 2024Article
- Neutralization of excessive levels of active TGF-β1 reduces MSC recruitment and differentiation to mitigate peritendinous adhesion.Bone research · 2023Article
- Defining the spatial-molecular map of fibrotic tendon healing and the drivers of Scleraxis-lineage cell fate and function.Cell reports · 2022Article
- A Simplified Murine Model to Imitate Flexor Tendon Adhesion Formation without Suture.Biomimetics (Basel, Switzerland) · 2022Article
- Characterization of scar tissue biomechanics during adult murine flexor tendon healing.Journal of the mechanical behavior of biomedical materials · 2022Article
- Article
- Disulfiram Suppressed Peritendinous Fibrosis Through Inhibiting Macrophage Accumulation and Its Pro-inflammatory Properties in Tendon Bone Healing.Frontiers in bioengineering and biotechnology · 2022Article
- Effects of tamoxifen on tendon homeostasis and healing: Considerations for the use of tamoxifen-inducible mouse models.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2021Article
- Scleraxis-lineage cell depletion improves tendon healing and disrupts adult tendon homeostasis.eLife · 2021Article
- Proceed with Caution: Mouse Deep Digit Flexor Tendon Injury Model.Plastic and reconstructive surgery. Global open · 2021Article
- NF-κB activation persists into the remodeling phase of tendon healing and promotes myofibroblast survival.Science signaling · 2020Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Tendon connects skeletal muscle and bone, facilitating movement of nearly the entire body. In the hand, flexor tendons (FTs) enable flexion of the fingers and general hand function. Injuries to the FTs are common, and satisfactory healing is often impaired due to excess scar tissue and adhesions between the tendon and surrounding tissue. However, little is known about the molecular and cellular components of FT repair. To that end, a murine model of FT repair that recapitulates many aspects of healing in humans, including impaired range of motion and decreased mechanical properties, has been developed and previously described. Here an in-depth demonstration of this surgical procedure is provided, involving transection and subsequent repair of the flexor digitorum longus (FDL) tendon in the murine hind paw. This technique can be used to conduct lineage analysis of different cell types, assess the effects of gene gain or loss-of-function, and to test the efficacy of pharmacological interventions in the healing process. However, there are two primary limitations to this model: i) the FDL tendon in the mid-portion of the murine hind paw, where the transection and repair occur, is not surrounded by a synovial sheath. Therefore this model does not account for the potential contribution of the sheath to the scar formation process. ii) To protect the integrity of the repair site, the FT is released at the myotendinous junction, decreasing the mechanical forces of the tendon, likely contributing to increased scar formation. Isolation of sufficient cells from the granulation tissue of the FT during the healing process for flow cytometric analysis has proved challenging; cytology centrifugation to concentrate these cells is an alternate method used, and allows for generation of cell preparations on which immunofluorescent labeling can be performed. With this method, quantification of cells or proteins of interest during FT healing becomes possible.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.