Evidence map›Paper›PMID 27683882›Full record

ArticleJournal of neurophysiology2016

The response of the vestibulosympathetic reflex to linear acceleration in the rat.

S B Yakushin, G P Martinelli, T Raphan, B Cohen

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurophysiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04976101 (A Pilot Study to Assess Sinusoidal Galvanic Vestibular Stimulation in Neurogenic Orthostatic Hypotension), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04976101 nawithdrawnnot on this mapstarted 2023, after this paper: background citation

A Pilot Study to Assess Sinusoidal Galvanic Vestibular Stimulation in Neurogenic Orthostatic Hypotension

TypeinterventionalSponsorHackensack Meridian HealthRan2023 to 2025Enrolled0ConditionsNeurogenic Orthostatic HypotensionArmsSinosuidal Galvanic Vestibular Stimulation, Placebo
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Modeling Interval Timing by Recurrent Neural Nets.Frontiers in integrative neuroscience · 2019
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

S B YakushinDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York; and.
G P MartinelliDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York; and.
T RaphanDepartment of Computer and Information Sciences, Brooklyn College, City University of New York, New York, New York.
B CohenDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York; and bernard.cohen@mssm.edu.
Icahn School of Medicine at Mount Sinai · USCity University of New York · US

Funding

Vestibular Control of the Vasovagal ResponseR01DC012573 · NIDCD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI COHEN, BERNARD · 2013 to 2015
$1.1M
NIDCD NIH HHS R01 DC012573
6 · The paper itself

Abstract

The vestibulosympathetic reflex (VSR) increases blood pressure (BP) upon arising to maintain blood flow to the brain. The optimal directions of VSR activation and whether changes in heart rate (HR) are associated with changes in BP are still not clear. We used manually activated pulses and oscillatory linear accelerations of 0.2-2.5 g along the naso-occipital, interaural, and dorsoventral axes in isoflurane-anesthetized, male Long-Evans rats. BP and HR were recorded with an intra-aortic sensor and acceleration with a three-dimensional accelerometer. Linear regressions of BP changes in accelerations along the upward, downward, and forward axes had slopes of ≈3-6 mmHg · g

Indexed as

AccelerationAnalysis of VarianceAnimalsBiomechanical PhenomenaBlood PressureHeart RateMaleOrientationRatsRats, Long-EvansReflexRespirationSympathetic Nervous SystemVestibule, Labyrinthanesthesiablood pressureheart ratelinear accelerationtranslation

Identifiers

PMID27683882
PMCPMC5141259
OpenAlexW2524194009

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.