ArticleJournal of spine surgery (Hong Kong)2016
Anterior cervical discectomy and fusion (ACDF) autograft versus graft substitutes: what do patients prefer?-A clinical study.
Article in Journal of spine surgery (Hong Kong), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04214535 (Anterior Cervical Disectomy And Fusion Using The Tritanium® C Anterior Cervical Cage For One Or Two-Levels), which is not on this map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Anterior Cervical Disectomy And Fusion Using The Tritanium® C Anterior Cervical Cage For One Or Two-Levels: A Clinical And Radiographic Analysis Pilot Study
Who cites it
21 citing papers in PubMed, 33 citations in OpenAlex.
- Speed and quality of interbody fusion in porous bioceramic AlJournal of orthopaedic surgery and research · 2023Trial
- Occurrence of ectopic ossification around the surgical site after using of ABM/P-15 in anterior cervical discectomy and fusion.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Influence of cage material, plating and vertebral bone quality on subsidence and long-term outcomes following anterior cervical discectomy and fusion-a retrospective analysis.Journal of spine surgery (Hong Kong) · 2026Article
- A nationwide registry study of surgical and patient-reported outcomes following anterior cervical discectomy and fusion: Part 1 - Synthetic cages versus autologous crista bone grafts.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Comparing the Immune Response to PEEK as an Implant Material with and without P-15 Peptide as Bone Graft Material in a Rabbit Long Bone Model.Bioengineering (Basel, Switzerland) · 2024Article
- Safety and Efficacy of Zero-Profile Polyetheretherketone (PEEK) Cages Filled with Biphasic Calcium Phosphate (BCP) in Anterior Cervical Discectomy and Fusion (ACDF): A Case Series.Journal of clinical medicine · 2024Article
- Article
- [Comparison of cervical fusion with autografting of fibula vs titanium cage].Revista medica del Instituto Mexicano del Seguro Social · 2023Article
- Clinical Outcomes and Cost Profiles for Cage and Allograft Anterior Cervical Discectomy and Fusion Procedures in the Adult Population: A Propensity Score-Matched Study.Asian spine journal · 2023Article
- Allograft Versus Autograft in Anterior Cervical Discectomy and Fusion: A Propensity-Matched Analysis.Cureus · 2022Article
- Structural Allograft Versus Synthetic Interbody Cage for Anterior Cervical Discectomy and Fusion: A Comparison of 1-Year Outcomes From a National Database.Global spine journal · 2021Article
- Using a mixture of local bone dust and morselized bone as graft materials in single- and double-level ACDF.BMC musculoskeletal disorders · 2021Article
- Short Plate with Screw Angle over 20 Degrees Improves the Radiologic Outcome in ACDF: Clinical Study.Journal of clinical medicine · 2021Article
- Analysis of the Variables Affecting the Incidence, Location, and Severity of Cage Subsidence Following Anterior Cervical Discectomy and Fusion Operation.International journal of spine surgery · 2020Article
- Comparison of the effectiveness and safety of bioactive glass ceramic to allograft bone for anterior cervical discectomy and fusion with anterior plate fixation.Neurosurgical review · 2020Article
- Integral Fixation Titanium/Polyetheretherketone Cages for Cervical Arthrodesis: Evolution of Cage Design and Early Radiological Outcomes and Fusion Rates.Orthopaedic surgery · 2019Article
- A single center retrospective clinical evaluation of anterior cervical discectomy and fusion comparing allograft spacers to silicon nitride cages.Journal of spine surgery (Hong Kong) · 2018Article
- Local delivery of a novel PTHrPRSC advances · 2018Article
- Relationship between depression and clinical outcome following anterior cervical discectomy and fusion.Journal of spine surgery (Hong Kong) · 2017Article
- Smith-Robinson procedure with and without Caspar plating as a treatment for cervical spondylotic myelopathy: A 26-year follow-up of 23 patients.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2017Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPatient dissatisfaction with donor site morbidity has led to the search for alternative grafting options and techniques. This report compares patient satisfaction rates between autograft and graft substitutes for anterior cervical discectomy and fusion (ACDF).
methodsThis study was performed with the approval of the local area health network ethics committee. Over a 9-year period, the author performed 574 ACDF procedures (697 levels). Of these, 22 patients had previous surgery with autograft, with a subsequent ACDF procedure performed using a graft substitute. Patients rated their satisfaction with pain, recovery, and preference of autograft versus a bone graft substitute. Graft substitutes used include: tricalcium phosphate/hydroxyapatite (TCP/HA) composite and iFactor placed within a polyetheretherketone (PEEK) cage.
resultsResults demonstrated that 21/22 patients achieved a solid fusion with the graft substitute. A total of 20/22 patients rated the autograft incision more painful than the anterior cervical incision, and 21/22 preferred the graft substitute. Three patients had adjacent segment disc replacement performed after autograft/ACDF. All patients reported preference for the total disc replacement (TDR) procedure in terms of recovery and postoperative pain.
conclusionsPatient satisfaction with bone graft substitutes is very high compared with autograft with all but one (21/22) preferring the graft substitute option. The author questions the traditional recommendation that autograft is the "gold standard" for ACDF. In modern age of graft substitutes, autograft should not be considered the gold standard, but an index option between other options for comparison.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.