Evidence map›Paper›PMID 27683615›Full record

ArticlePulmonary circulation2016

Pregnancy as a possible trigger for heritable pulmonary arterial hypertension.

Maude Limoges, David Langleben, Benjamin D Fox, Roberta Shear, Paul Wieczorek, Lawrence G Rudski, Andrew M Hirsch, Robert D Schlesinger, Lyda Lesenko

Open access · bronzeAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Pulmonary circulation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

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  7. Three novelHuman genome variation · 2017
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Maude LimogesCenter for Pulmonary Vascular Disease, Jewish General Hospital and McGill University, Montreal, Quebec, Canada.
David LanglebenCenter for Pulmonary Vascular Disease, Jewish General Hospital and McGill University, Montreal, Quebec, Canada.
Benjamin D FoxPulmonary Division, Rabin Medical Center and Tel Aviv University, Tel Aviv, Israel.
Roberta ShearDepartment of Obstetrics, Jewish General Hospital and McGill University, Montreal, Quebec, Canada.
Paul WieczorekDepartment of Anesthesiology, Jewish General Hospital and McGill University, Montreal, Quebec, Canada.
Lawrence G RudskiCenter for Pulmonary Vascular Disease, Jewish General Hospital and McGill University, Montreal, Quebec, Canada.
Andrew M HirschCenter for Pulmonary Vascular Disease, Jewish General Hospital and McGill University, Montreal, Quebec, Canada.
Robert D SchlesingerCenter for Pulmonary Vascular Disease, Jewish General Hospital and McGill University, Montreal, Quebec, Canada.
Lyda LesenkoCenter for Pulmonary Vascular Disease, Jewish General Hospital and McGill University, Montreal, Quebec, Canada.
Jewish General Hospital · CATel Aviv University · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It is unclear whether pregnancy is a trigger or accelerant for idiopathic pulmonary arterial hypertension (PAH). Alternatively, its frequency close to the onset of symptoms and diagnosis in the idiopathic PAH population may represent a coincidence in a disease that predominates in young women. We describe a carrier of a BMPR2 gene mutation who had an uneventful first pregnancy but had aggressive PAH during her second pregnancy and now has ongoing heritable PAH. The possible role of pregnancy as a trigger in this vulnerable patient is discussed. Databases of patients with heritable PAH should be explored to see whether pregnancy is related to overt manifestation of the disease.

Indexed as

BMPR2pregnancypulmonary arterial hypertensionright ventricle

Identifiers

PMID27683615
PMCPMC5019091
OpenAlexW2330223682

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.