ArticleFrontiers in microbiology2016
Insights into the Quorum Sensing Regulon of the Acidophilic Acidithiobacillus ferrooxidans Revealed by Transcriptomic in the Presence of an Acyl Homoserine Lactone Superagonist Analog.
Article in Frontiers in microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 39 citations in OpenAlex.
- Identification and characterization of quorum-quenching enzyme AiiF fromApplied and environmental microbiology · 2026Article
- Glucose-6-Phosphate 1-Epimerase Responds to Phosphate Starvation by Regulating Carbohydrate Homeostasis in Rice andPlants (Basel, Switzerland) · 2025Article
- Synthesis of N-acyl-homoserine lactones analogs for improving the potential application of Acidithiobacillus thiooxidans in bioleaching.Archives of microbiology · 2025Article
- Roles and Regulation of Quorum Sensing of Acidophiles in Bioleaching: A Review.Microorganisms · 2024Review
- Design and synthesis of quorum-sensing agonist for improving biofilm formation and the application ofFrontiers in microbiology · 2024Article
- Influence of mobile genetic elements and insertion sequences in long- and short-term adaptive processes of Acidithiobacillus ferrooxidans strains.Scientific reports · 2023Article
- Overexpression of quorum sensing genes inBiotechnology reports (Amsterdam, Netherlands) · 2023Article
- Functional analysis ofFrontiers in plant science · 2023Article
- Recent progress in the application of omics technologies in the study of bio-mining microorganisms from extreme environments.Microbial cell factories · 2021Review
- Heterocyclic Chemistry Applied to the Design ofMolecules (Basel, Switzerland) · 2021Review
- Diffusible signal factor signaling controls bioleaching activity and niche protection in the acidophilic, mineral-oxidizing leptospirilli.Scientific reports · 2021Article
- The substrate-dependent regulatory effects of the AfeI/R system in Acidithiobacillus ferrooxidans reveals the novel regulation strategy of quorum sensing in acidophiles.Environmental microbiology · 2021Article
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- Newly IsolatedFrontiers in microbiology · 2020Article
- Effect of Sodium Chloride on Pyrite Bioleaching and Initial Attachment byFrontiers in microbiology · 2020Article
- Biofilms: The Microbial "Protective Clothing" in Extreme Environments.International journal of molecular sciences · 2019Review
- Effect of COFrontiers in microbiology · 2019Article
- Proteomics Reveal Enhanced Oxidative Stress Responses and Metabolic Adaptation inFrontiers in microbiology · 2019Article
- Acidithiobacillus ferrooxidans and its potential application.Extremophiles : life under extreme conditions · 2018Review
- Article
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While a functional quorum sensing system has been identified in the acidophilic chemolithoautotrophic Acidithiobacillus ferrooxidans ATCC 23270(T) and shown to modulate cell adhesion to solid substrates, nothing is known about the genes it regulates. To address the question of how quorum sensing controls biofilm formation in A. ferrooxidans (T), the transcriptome of this organism in conditions in which quorum sensing response is stimulated by a synthetic superagonist AHL (N-acyl homoserine lactones) analog has been studied. First, the effect on biofilm formation of a synthetic AHL tetrazolic analog, tetrazole 9c, known for its agonistic QS activity, was assessed by fluorescence and electron microscopy. A fast adherence of A. ferrooxidans (T) cells on sulfur coupons was observed. Then, tetrazole 9c was used in DNA microarray experiments that allowed the identification of genes regulated by quorum sensing signaling, and more particularly, those involved in early biofilm formation. Interestingly, afeI gene, encoding the AHL synthase, but not the A. ferrooxidans quorum sensing transcriptional regulator AfeR encoding gene, was shown to be regulated by quorum sensing. Data indicated that quorum sensing network represents at least 4.5% (141 genes) of the ATCC 23270(T) genome of which 42.5% (60 genes) are related to biofilm formation. Finally, AfeR was shown to bind specifically to the regulatory region of the afeI gene at the level of the palindromic sequence predicted to be the AfeR binding site. Our results give new insights on the response of A. ferrooxidans to quorum sensing and on biofilm biogenesis.
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