ArticleProceedings. Biological sciences2016
Maternal stress has divergent effects on gene expression patterns in the brains of male and female threespine stickleback.
Article in Proceedings. Biological sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 39 citations in OpenAlex.
- Building neuroanatomical resources for three-spined sticklebacks: Brain areas important for social behavior.bioRxiv : the preprint server for biology · 2026Article
- Persistent maternal age effects on male offspring fitness traits in a wild mammal population.Evolution letters · 2025Article
- Effects of DNA Methylation of HPA-Axis Genes of F1 Juvenile Induced by Maternal Density Stress on Behavior and Immune Traits in Root Voles (Animals : an open access journal from MDPI · 2024Article
- Evolutionary divergence of subgenomes in common carp provides insights into speciation and allopolyploid success.Fundamental research · 2024Article
- The interplay between sperm-mediated and care-mediated paternal effects in threespine sticklebacks.Animal behaviour · 2021Article
- Does parental angling selection affect the behavior or metabolism of brown trout parr?Ecology and evolution · 2021Article
- Sex-specific plasticity across generations I: Maternal and paternal effects on sons and daughters.The Journal of animal ecology · 2020Article
- Early Developmental Stress Affects Subsequent Gene Expression Response to an Acute Stress in Atlantic Salmon: An Approach for Creating Robust Fish for Aquaculture?G3 (Bethesda, Md.) · 2019Article
- The development of individual differences in cooperative behaviour: maternal glucocorticoid hormones alter helping behaviour of offspring in wild meerkats.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Article
- Personal and transgenerational cues are nonadditive at the phenotypic and molecular level.Nature ecology & evolution · 2018Article
- The DNA Methylation Landscape of Stickleback Reveals Patterns of Sex Chromosome Evolution and Effects of Environmental Salinity.Genome biology and evolution · 2018Article
- Persistent and plastic effects of temperature on DNA methylation across the genome of threespine stickleback (Proceedings. Biological sciences · 2017Article
- Parenting in Animals.Current opinion in psychology · 2017Article
- Maternal stress has divergent effects on gene expression patterns in the brains of male and female threespine stickleback.Proceedings. Biological sciences · 2016Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Maternal stress can have long-term effects on neurodevelopment that can influence offspring performance and population evolutionary trajectories. To examine the mechanistic basis for these neurodevelopmental effects of maternal stress, we used RNA-seq to assess differential gene expression across the brain transcriptome of adult male and female threespine stickleback (Gasterosteus aculeatus) from stressed and unstressed mothers. We identified sexually divergent effects of maternal stress on the brain transcriptome. In males, genes that were upregulated by maternal stress were enriched for processes involved in synaptic function and organization and steroid hormone-mediated signalling pathways, whereas in females genes that were upregulated by maternal stress were enriched for processes involved in protein translation and metabolic functions. The expression of several genes involved in the hypothalamic-pituitary-interrenal response to stress and epigenetic processes such as the regulation of DNA methylation patterns and miRNAs increased in males and not in females. These data suggest that maternal stress has markedly different effects on cellular pathways in the brains of male and female offspring of mothers that are exposed to stress, which could have important implications when assessing the long-term ecological and evolutionary impacts of stress across generations.
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