ArticleProceedings. Biological sciences2016
Host coevolution alters the adaptive landscape of a virus.
Article in Proceedings. Biological sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- A recurrent adaptive mutation in the transmembrane 2B protein of an insect picorna-like virus in a nonnative host.Journal of virology · 2026Article
- Temperate versus virulent phage lifestyle impacts microdiversity in soil environments.ISME communications · 2026Article
- Competition-driven eco-evolutionary feedback reshapes bacteriophage lambda's fitness landscape and enables speciation.Nature communications · 2024Article
- Stepwise Evolution of E. coli C and ΦX174 Reveals Unexpected Lipopolysaccharide (LPS) Diversity.Molecular biology and evolution · 2023Article
- Experimental Evolution of the TolC-Receptor Phage U136B Functionally Identifies a Tail Fiber Protein Involved in Adsorption through Strong Parallel Adaptation.Applied and environmental microbiology · 2023Article
- A lipopolysaccharide-dependent phage infects a pseudomonad phytopathogen and can evolve to evade phage resistance.Environmental microbiology · 2022Article
- Host-parasite coevolution promotes innovation through deformations in fitness landscapes.eLife · 2022Article
- Leapfrog dynamics in phage-bacteria coevolution revealed by joint analysis of cross-infection phenotypes and whole genome sequencing.Ecology letters · 2022Article
- Evolution of pathogen tolerance and emerging infections: A missing experimental paradigm.eLife · 2021Review
- Effects of historical co-infection on host shift abilities of exploitative and competitive viruses.Evolution; international journal of organic evolution · 2021Article
- Coevolutionary phage training leads to greater bacterial suppression and delays the evolution of phage resistance.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Sustained coevolution of phage Lambda andMicrobiology (Reading, England) · 2021Article
- Evolution along the parasitism-mutualism continuum determines the genetic repertoire of prophages.PLoS computational biology · 2020Article
- Pleiotropy complicates a trade-off between phage resistance and antibiotic resistance.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Experimental Evolution of Innovation and Novelty.Trends in ecology & evolution · 2019Review
- Review
- Secondary contact between diverged host lineages entails ecological speciation in a European hantavirus.PLoS biology · 2019Article
- Adaptation, chance, and history in experimental evolution reversals to unicellularity.Evolution; international journal of organic evolution · 2019Article
- Experimental Design, Population Dynamics, and Diversity in Microbial Experimental Evolution.Microbiology and molecular biology reviews : MMBR · 2018Review
- Article
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3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The origin of new and complex structures and functions is fundamental for shaping the diversity of life. Such key innovations are rare because they require multiple interacting changes. We sought to understand how the adaptive landscape led to an innovation whereby bacteriophage λ evolved the new ability to exploit a receptor, OmpF, on Escherichia coli cells. Previous work showed that this ability evolved repeatedly, despite requiring four mutations in one virus gene. Here, we examine how this innovation evolved by studying six intermediate genotypes of λ isolated during independent transitions to exploit OmpF and comparing them to their ancestor. All six intermediates showed large increases in their adsorption rates on the ancestral host. Improvements in adsorption were offset, in large part, by the evolution of host resistance, which occurred by reduced expression of LamB, the usual receptor for λ. As a consequence of host coevolution, the adaptive landscape of the virus changed such that selection favouring four of the six virus intermediates became stronger after the host evolved resistance, thereby accelerating virus populations along the path to using the new OmpF receptor. This dependency of viral fitness on host genotype thus shows an important role for coevolution in the origin of the new viral function.
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