ReviewClinical reviews in bone and mineral metabolism
Synchrotron Imaging Assessment of Bone Quality.
Review in Clinical reviews in bone and mineral metabolism. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Advancements in High-Resolution Computed Tomography: Revolutionising Bone Health Micro-Research.Bioengineering (Basel, Switzerland) · 2025Article
- Runaway resorption of microcracks contributes to age-related hip-fracture patients.Scientific reports · 2025Article
- Biomechanics of the Human Osteochondral Unit: A Systematic Review.Materials (Basel, Switzerland) · 2024Review
- Osteoporosis and Covid-19: Detected similarities in bone lacunar-level alterations via combined AI and advanced synchrotron testing.Materials & design · 2023Article
- Characterizing the Mechanical Behavior of Bone and Bone Surrogates in Compression Using pQCT.Materials (Basel, Switzerland) · 2022Article
- Computed Tomography as a Characterization Tool for Engineered Scaffolds with Biomedical Applications.Materials (Basel, Switzerland) · 2021Review
- Beamline K11 DIAD: a new instrument for dual imaging and diffraction at Diamond Light Source.Journal of synchrotron radiation · 2021Article
- I22: SAXS/WAXS beamline at Diamond Light Source - an overview of 10 years operation.Journal of synchrotron radiation · 2021Article
- ViceCT and whiceCT for simultaneous high-resolution visualization of craniofacial, brain and ventricular anatomy from micro-computed tomography.Scientific reports · 2020Article
- Nanoscale mechanisms in age-related hip-fractures.Scientific reports · 2020Article
- Sub-trabecular strain evolution in human trabecular bone.Scientific reports · 2020Article
- Next-generation imaging of the skeletal system and its blood supply.Nature reviews. Rheumatology · 2019Review
- Impairment of bone microstructure and upregulation of osteoclastogenic markers in spontaneously hypertensive rats.Scientific reports · 2019Article
- Evaluating Biogenicity on the Geological Record With Synchrotron-Based Techniques.Frontiers in microbiology · 2019Review
- Advancements and frontiers in nano-based 3D and 4D scaffolds for bone and cartilage tissue engineering.International journal of nanomedicine · 2019Review
- Measuring bone stiffness using spherical indentation.PloS one · 2018Article
- Investigating the Mechanical Characteristics of Bone-Metal Implant Interface UsingFrontiers in bioengineering and biotechnology · 2018Article
- The effect of long-term bisphosphonate therapy on trabecular bone strength and microcrack density.Bone & joint research · 2017Article
- Vibrational spectroscopic techniques to assess bone quality.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017Review
- Long-term effects of bisphosphonate therapy: perforations, microcracks and mechanical properties.Scientific reports · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Bone is a complex hierarchical structure, and its principal function is to resist mechanical forces and fracture. Bone strength depends not only on the quantity of bone tissue but also on the shape and hierarchical structure. The hierarchical levels are interrelated, especially the micro-architecture, collagen and mineral components; hence, analysis of their specific roles in bone strength and stiffness is difficult. Synchrotron imaging technologies including micro-CT and small/wide angle X-ray scattering/diffraction are becoming increasingly popular for studying bone because the images can resolve deformations in the micro-architecture and collagen-mineral matrix under in situ mechanical loading. Synchrotron cannot be directly applied in vivo due to the high radiation dose but will allow researchers to carry out systematic multifaceted studies of bone ex vivo. Identifying characteristics of aging and disease will underpin future efforts to generate novel devices and interventional therapies for assessing and promoting healthy aging. With our own research work as examples, this paper introduces how synchrotron imaging technology can be used with in situ testing in bone research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.