Evidence map›Paper›PMID 27683235›Full record

ArticleJournal of neurovirology2017

Induction of varicella zoster virus DNA replication in dissociated human trigeminal ganglia.

Randall J Cohrs, Hussain Badani, Nicholas L Baird, Teresa M White, Bridget Sanford, Don Gilden

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurovirology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

  1. Biological relevance ofMicrobiology and molecular biology reviews : MMBR · 2025
    Review
  2. Article
  3. Varicella Zoster Virus Neuronal Latency and Reactivation Modeled in Vitro.Current topics in microbiology and immunology · 2023
    Review
  4. Article
  5. Herpesviral Latency-Common Themes.Pathogens (Basel, Switzerland) · 2020
    Review
  6. Review
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Randall J CohrsDepartment of Neurology, University of Colorado School of Medicine, 12700 E. 19th Avenue, Box B-182, Aurora, CO, 80045, USA. randall.cohrs@ucdenver.edu.
Hussain BadaniDepartment of Neurology, University of Colorado School of Medicine, 12700 E. 19th Avenue, Box B-182, Aurora, CO, 80045, USA.
Nicholas L BairdDepartment of Neurology, University of Colorado School of Medicine, 12700 E. 19th Avenue, Box B-182, Aurora, CO, 80045, USA.
Teresa M WhiteDepartment of Neurology, University of Colorado School of Medicine, 12700 E. 19th Avenue, Box B-182, Aurora, CO, 80045, USA.
Bridget SanfordDepartment of Neurology, University of Colorado School of Medicine, 12700 E. 19th Avenue, Box B-182, Aurora, CO, 80045, USA.
Don GildenDepartment of Neurology, University of Colorado School of Medicine, 12700 E. 19th Avenue, Box B-182, Aurora, CO, 80045, USA.
University of Colorado Denver · US

Funding

VARICELLA ZOSTER VIRUS VASCULOPATHY: CHANGING CLINICAL PRACTICEP01AG032958 · NIA · UNIVERSITY OF COLORADO DENVER · PI COHRS, RANDALL J. · 2009 to 2023
$30.3M
NEUROVIROLOGY-MOLECULAR BIOLOGYT32NS007321 · NINDS · UNIVERSITY OF COLORADO DENVER · PI GILDEN, DONALD · 1988 to 2014
$2.3M
Neurobiology of Varicella Zoster VirusR01NS093716 · NINDS · UNIVERSITY OF COLORADO DENVER · PI COHRS, RANDALL J. · 2015 to 2019
$2.2M
Prevention of VZV ReactivationR01NS082228 · NINDS · UNIVERSITY OF COLORADO DENVER · PI COHRS, RANDALL J. · 2013 to 2017
$1.7M
NIA NIH HHS P01 AG032958NINDS NIH HHS R01 NS082228NINDS NIH HHS R01 NS093716NINDS NIH HHS T32 NS007321
6 · The paper itself

Abstract

Varicella zoster virus (VZV), a human neurotropic alphaherpesvirus, becomes latent after primary infection and reactivates to produce zoster. To study VZV latency and reactivation, human trigeminal ganglia removed within 24 h after death were mechanically dissociated, randomly distributed into six-well tissue culture plates and incubated with reagents to inactivate nerve growth factor (NGF) or phosphoinositide 3-kinase (PI3-kinase) pathways. At 5 days, VZV DNA increased in control and PI3-kinase inhibitor-treated cultures to the same extent, but was significantly more abundant in anti-NGF-treated cultures (p = 0.001). Overall, VZV DNA replication is regulated in part by an NGF pathway that is PI3-kinase-independent.

Indexed as

DNA ReplicationVirus ActivationVirus ReplicationAdultAgedAntibodies, NeutralizingAutopsyDNA, ViralGene Expression RegulationHerpesvirus 3, HumanHerpes ZosterHost-Pathogen InteractionsHumansMaleMiddle AgedNerve Growth FactorAntibodies, NeutralizingDNA, ViralNerve Growth FactorPhosphatidylinositol 3-KinasesPhosphoinositide-3 Kinase InhibitorsProtein Kinase InhibitorsHumanLatencyNerve growth factorPhosphoinositide-3-kinaseTrigeminal ganglionVZV

Identifiers

PMID27683235
PMCPMC5464606
OpenAlexW2525657944

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.