ArticleAging cell2017
Uncoupling associations of risk alleles with endophenotypes and phenotypes: insights from the ApoB locus and heart-related traits.
Article in Aging cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.
- Strong impact of natural-selection-free heterogeneity in genetics of age-related phenotypes.Aging · 2018Pooled it
- Associations of the APOB rs693 and rs17240441 polymorphisms with plasma APOB and lipid levels: a meta-analysis.Lipids in health and disease · 2017Pooled it
- The Joint Effect of Body Mass Index and Serum Lipid Levels on Incident Dementia among Community-Dwelling Older Adults.The journal of nutrition, health & aging · 2023Article
- Genome-wide analysis of genetic predisposition to common polygenic cancers.Journal of applied genetics · 2022Article
- Mediation of the APOE associations with Alzheimer's and coronary heart diseases through body mass index and lipids.GeroScience · 2022Article
- Genetic Association Studies of Age-Related Traits: New Perspectives.Advances in geriatric medicine and research · 2021Article
- Quantitative and Qualitative Role of Antagonistic Heterogeneity in Genetics of Blood Lipids.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Article
- Influence of multiple apolipoprotein A-I and B genetic variations on insulin resistance and metabolic syndrome in obstructive sleep apnea.Nutrition & metabolism · 2020Article
- Genome-wide analysis of genetic predisposition to Alzheimer's disease and related sex disparities.Alzheimer's research & therapy · 2019Article
- Pleiotropic Meta-Analysis of Age-Related Phenotypes Addressing Evolutionary Uncertainty in Their Molecular Mechanisms.Frontiers in genetics · 2019Article
- Emerging Role of Precision Medicine in Cardiovascular Disease.Circulation research · 2018Review
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
Traditionally, genomewide association studies (GWAS) have emphasized the benefits of large samples in the analyses of age-related traits rather than their specific properties. We adopted a realistic concept of genetic susceptibility to inherently heterogeneous, age-related traits driven by the elusive role of evolution in their properties. We analyzed in detail the associations of rs693 and rs562338 polymorphisms representing the Apolipoprotein B locus with endophenotypes (total cholesterol [TC] and high-density lipoprotein cholesterol) and phenotypes (myocardial infarction [MI] and survival) in four large-scale studies, which include 20 748 individuals with 2357 MI events. We showed that a strong, robust predisposition of rs693 and rs562338 to TC (β = 0.72, P = 7.7 × 10
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.