Evidence map›Paper›PMID 27683182›Full record

Trial reportClinical cancer research : an official journal of the American Association for Cancer Research2017

A Phase II Trial of Abiraterone Combined with Dutasteride for Men with Metastatic Castration-Resistant Prostate Cancer.

Rana R McKay, Lillian Werner, Elahe A Mostaghel, Rosina Lis, Olga Voznesensky, Zhenwei Zhang, Brett T Marck, Alvin M Matsumoto, Liran Domachevsky, Katherine A Zukotynski and 6 more

Erratum issued Registry-linked trialOpen access · greenAbstract readClinical Trial, Phase II
In one paragraph

Trial report in Clinical cancer research : an official journal of the American Association for Cancer Research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT01393730 (Phase II Trial of Abiraterone Acetate Combined With Dutasteride With Correlative Assessment of Tumor Androgen Levels and Androgen Receptor Sequence and Signaling at Baseline and at Progression), which is not on this map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01393730 phase2completednot on this map

Phase II Trial of Abiraterone Acetate Combined With Dutasteride With Correlative Assessment of Tumor Androgen Levels and Androgen Receptor Sequence and Signaling at Baseline and at Progression

TypeinterventionalSponsorMary-Ellen Taplin, MDRan2011 to 2017Enrolled40ConditionsProstate CancerArmsAbiraterone acetate, Dutasteride, Prednisone
3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 32 citations in OpenAlex.

  1. Circulating and Intratumoral Adrenal Androgens Correlate with Response to Abiraterone in Men with Castration-Resistant Prostate Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2021
    Trial
  2. Trial
  3. Trial
  4. Article
  5. Review
  6. The role of 11-oxygenated androgens in prostate cancer.Endocrine oncology (Bristol, England) · 2023
    Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Determination of Abiraterone and Its Metabolites in Human Serum by LC-ESI-TOF/MS Using Solid-phase Extraction.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2021
    Article
  12. Article
  13. Article
  14. Intracrinology-revisited and prostate cancer.The Journal of steroid biochemistry and molecular biology · 2020
    Review
  15. Review
  16. Article
  17. Article
  18. Downregulation ofCancer research · 2018
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 2 countries.

Rana R McKayDana-Farber Cancer Institute, Boston, Massachusetts.
Lillian WernerDana-Farber Cancer Institute, Boston, Massachusetts.
Elahe A MostaghelUniversity of Washington, Seattle, Washington.
Rosina LisDana-Farber Cancer Institute, Boston, Massachusetts.
Olga VoznesenskyBeth Israel Deaconess Medical Center, Boston, Massachusetts.
Zhenwei ZhangDana-Farber Cancer Institute, Boston, Massachusetts.
Brett T MarckVeterans Affairs Puget Sound Health Care System, Seattle, Washington.
Alvin M MatsumotoUniversity of Washington, Seattle, Washington.
Liran DomachevskyBeilinson Hospital, Petah Tikva, Israel.
Katherine A ZukotynskiMcMaster University, Ontario, Canada.
Manoj BhasinBeth Israel Deaconess Medical Center, Boston, Massachusetts.
Glenn J BubleyBeth Israel Deaconess Medical Center, Boston, Massachusetts.
Bruce MontgomeryUniversity of Washington, Seattle, Washington.
Philip W KantoffDana-Farber Cancer Institute, Boston, Massachusetts.
Steven P BalkBeth Israel Deaconess Medical Center, Boston, Massachusetts.
Mary-Ellen TaplinDana-Farber Cancer Institute, Boston, Massachusetts. Mary_Taplin@DFCI.harvard.edu.
Dana-Farber Cancer Institute · USBeth Israel Deaconess Medical Center · USUniversity of Washington · USKettering University · USMcMaster University · CAVA Puget Sound Health Care System · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
TRANSCRIPTOME AND PROTEOME STRATIFICATION OF PROSTATE ADENOCARCINOMA PHENOTYPESP50CA097186 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI PETER S NELSON · 2002 to 2026
$58.1M
Tumor and Circulating Markers as Links Between Obesity and Lethal Prostate CanceP50CA090381 · NCI · DANA-FARBER CANCER INSTITUTE · PI KANTOFF, PHILIP W · 2002 to 2017
$36.2M
Steroid Metabolism in Castration-Resistant Prostate CancerP01CA163227 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI PETER S NELSON · 2013 to 2026
$25.0M
NCI NIH HHS P01 CA163227NCI NIH HHS P30 CA008748NCI NIH HHS P50 CA090381NCI NIH HHS P50 CA097186
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AgedAndrogensAndrostenesDisease ProgressionDrug Resistance, NeoplasmDutasterideHumansMaleMiddle AgedNeoplasm MetastasisProstatic Neoplasms, Castration-ResistantRadiographyReceptors, AndrogenabirateroneAndrogensAndrostenesAR protein, humanDutasterideReceptors, Androgen

Identifiers

PMID27683182
PMCPMC5315609
OpenAlexW2525038995

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.