Evidence map›Paper›PMID 27683159›Full record

ArticleAlzheimer's research & therapy2016

Regional tau deposition measured by [

Laure Saint-Aubert, Ove Almkvist, Konstantinos Chiotis, Rita Almeida, Anders Wall, Agneta Nordberg

Open access · goldAbstract read
In one paragraph

Article in Alzheimer's research & therapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 55 citations in OpenAlex.

  1. The Role of Amyloid-β and Tau PET in the New Era of Alzheimer Disease Therapies.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Review
  2. Article
  3. Article
  4. Review
  5. The impact of tau deposition and hypometabolism on cognitive impairment and longitudinal cognitive decline.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. [Molecular psychiatry · 2021
    Article
  14. Article
  15. Associations between Vascular Function and Tau PET Are Associated with Global Cognition and Amyloid.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020
    Article
  16. Characterization ofMolecules (Basel, Switzerland) · 2020
    Article
  17. Review
  18. The A/T/N model applied through imaging biomarkers in a memory clinic.European journal of nuclear medicine and molecular imaging · 2020
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Laure Saint-AubertKarolinska Institutet, Department NVS, Center for Alzheimer Research, Division of Translational Alzheimer Neurobiology, Novum 5th floor, Huddinge, 141 57, Sweden.
Ove AlmkvistKarolinska Institutet, Department NVS, Center for Alzheimer Research, Division of Translational Alzheimer Neurobiology, Novum 5th floor, Huddinge, 141 57, Sweden.
Konstantinos ChiotisKarolinska Institutet, Department NVS, Center for Alzheimer Research, Division of Translational Alzheimer Neurobiology, Novum 5th floor, Huddinge, 141 57, Sweden.
Rita AlmeidaDepartment of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Anders WallPET Centre, Uppsala University Hospital, Uppsala, Sweden.
Agneta NordbergKarolinska Institutet, Department NVS, Center for Alzheimer Research, Division of Translational Alzheimer Neurobiology, Novum 5th floor, Huddinge, 141 57, Sweden. agneta.nordbergt@ki.se.
Karolinska Institutet · SEKarolinska University Hospital · SEUppsala University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe recent development of tau-specific positron emission tomography (PET) tracers has allowed in vivo quantification of regional tau deposition and offers the opportunity to monitor the progression of tau pathology along with cognitive impairment. In this study, we investigated the relationships of cerebral tau deposition ([

methodsNine patients diagnosed with AD dementia and 11 with prodromal AD (mild cognitive impairment, amyloid-positive on [

resultsSignificant negative associations were found between [

conclusionsThese findings suggest a mediating role for local glucose metabolism in the observed association between in vivo tau deposition and concomitant cognitive impairment in AD.

Indexed as

CognitionMemoryMetabolismPositron emission tomography (PET)Tau imaging

Identifiers

PMID27683159
PMCPMC5041516
OpenAlexW2511615488

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.