ArticleInternational journal of colorectal disease2016
Ileal pouch-anal anastomosis 20 years later: is it still a good surgical option for patients with ulcerative colitis?
Article in International journal of colorectal disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Prevalence of 'pouch failure' of the ileoanal pouch in ulcerative colitis: a systematic review and meta-analysis.International journal of colorectal disease · 2022Pooled it
- The Incidence and Definition of Crohn's Disease of the Pouch: A Systematic Review and Meta-analysis.Inflammatory bowel diseases · 2019Pooled it
- Trial
- Article
- Structural and epitope characterization of anti-DEFA5 monoclonal antibodies clones 1A8 and 4F5 for inflammatory bowel disease subtype diagnostics.International journal of biological macromolecules · 2025Article
- The prevalence of pouch fistulas in ulcerative colitis following restorative proctocolectomy: a systematic review and meta-analysis.Intestinal research · 2025Article
- Dynamic ileal pouch emptying studies.Abdominal radiology (New York) · 2023Review
- Quality of Life in Inflammatory Bowel Diseases (IBDs) Patients after Surgery.Reviews on recent clinical trials · 2022Review
- Ileal Pouch-anal Anastomosis Complications and Pouch Failure: A systematic review and meta-analysis.Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2021Article
- Transanal proctocolectomy and ileal pouch-anal anastomosis (TaIPAA) for ulcerative colitis: medium term functional outcomes in a single centre.BMC surgery · 2021Article
- Surgical results and quality of life of patients submitted to restorative proctocolectomy and ileal pouch-anal anastomosis.Revista do Colegio Brasileiro de Cirurgioes · 2021Article
- Adjunctive Pharmacotherapy Use in Patients With Ileal Pouch-Anal Anastomosis (IPAA).Crohn's & colitis 360 · 2020Article
- Timing of Surgery to Treat Ulcerative Colitis: An Investigation Focused on Japanese Adults.Inflammatory intestinal diseases · 2020Article
- Anxiety, depression, and inflammation after restorative proctocolectomy.International journal of colorectal disease · 2018Article
- The functional outcome and factors influencing the quality of life after ileal pouch anal anastomosis in patients with ulcerative colitis.Surgery today · 2018Article
- Case Report and Literature Review Illustrating the Clinical, Endoscopic, Radiologic, and Histopathologic Findings with Prepouch Ileitis after IPAA and Restorative Proctocolectomy for Refractory Ulcerative Colitis.Case reports in gastrointestinal medicine · 2018Article
- [How does the ileoanal pouch keep its promises? : Functioning of the ileoanal pouch after restorative proctocolectomy].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2017Review
- [Restorative proctocolectomy for ulcerative colitis : Long-term functional results and quality of life].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2017Review
- Neoterminal Ileal Polyposis and Ulceration after Restorative Proctocolectomy with a Current Review of the Literature.Case reports in gastroenterologyArticle
- Quality of life of ulcerative colitis patients treated surgically with proctocolectomy and J-pouch formation: a comparative study before surgery and after closure of the defunctioning ileostomy.Annals of gastroenterologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeShort-term results after ileo-pouch anal anastomosis (IPAA) are well established; data are conflicting in long-standing patients. We retrospectively evaluated long-term complications and functional results after follow-up longer than 20 years.
methodsTwo hundred five patients with follow-up longer than 20 years have been identified out of 1112 IPAA performed in our institution; of these, 20 cases were lost at follow-up or decline to take part at the study. We evaluated long-term complications and failure rate also according to changes in histological diagnosis. Changes in functional results and quality of life (QoL) were analyzed at 5 and 20 years after IPAA.
resultsPouch failure rate was 10.8 % (35 % due to misdiagnosed Crohn). Incidences of fistulas, anastomotic stenosis, chronic pouchitis, and pre-pouch ileitis were 17.3, 12.9, 28.6, and 7.6 %, respectively. Most of the patients reported good functional outcomes. Day-time evacuations at 5 and after 20 years were 4.3 and 4.8 (p = n.s.) while during night-time were 0.8 and 1.2 (p < 0.05). Urgency was 6 and 9.4 % (p = n.s.), respectively; need of antimotility drugs was 16 and 35 % (p < 0.001). Dietary limitations and work restrictions were similar over time. Only sexuality got worse during follow-up. Satisfaction for surgery was always high and it did not change over time.
conclusionIPAA is still an excellent surgical option for UC with a low rate of pouch failure even after more than 20 years. Despite a slight worsening of functional results over time, the QoL remained high and most patients expressed satisfaction with the procedure and were willing to recommend it to others.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.