Evidence map›Paper›PMID 27682597›Full record

ArticleJournal of cellular physiology2017

p120-Catenin Is Required for Dietary Calcium Suppression of Oral Carcinogenesis in Mice.

Zhongjian Xie, Yuan Yuan, Yi Jiang, Chandrama Shrestha, Ying Chen, Liyan Liao, Shangli Ji, Xiaoge Deng, Eryuan Liao, Daniel D Bikle

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cellular physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 2 pooled it
0.3field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 syntheses or guidelines pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Zhongjian XieDepartment of Endocrinology and Metabolism, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Yuan YuanDepartment of Endocrinology and Metabolism, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Yi JiangDepartment of Pathology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Chandrama ShresthaDepartment of Endocrinology and Metabolism, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Ying ChenInstitute of Traditional Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
Liyan LiaoDepartment of Pathology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Shangli JiDepartment of Endocrinology and Metabolism, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Xiaoge DengDepartment of Endocrinology and Metabolism, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Eryuan LiaoDepartment of Endocrinology and Metabolism, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Daniel D BikleEndocrine Unit, Veterans Affairs Medical Center, Northern California Institute for Research and Education and University of California, San Francisco, California.
Second Xiangya Hospital of Central South University · CNCentral South University · CNUniversity of California, San Francisco · USChinese Academy of Medical Sciences & Peking Union Medical College · CN

Funding

YEAST THREONINE &SERINE KINASESP41RR001614 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ORTIZ DE MONTELLANO, PAUL R · 1985 to 2011
$24.1M
Vitamin D Receptor Coactivators in KeratinocytesR01AR050023 · NIAMS · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI BIKLE, DANIEL DAVID · 2004 to 2014
$3.4M
VITAMIN D AND THE DIFFERENTIATION OF KERATINOCYTESR01AR038386 · NIAMS · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI BIKLE, DANIEL DAVID · 1987 to 2003
$1.1M
Role of p120-catenin in oral squamous cell carcinomaR21DE019529 · NIDCR · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI XIE, ZHONGJIAN · 2009 to 2010
$424k
The role of PIKE-S in mediating EGFR mitogenic signaling in OSCC cellsR03DE018001 · NIDCR · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI XIE, ZHONGJIAN · 2007 to 2008
$157k
Role of vitamin D and calcium signaling in wound healingI01BX001066 · VA · VETERANS AFFAIRS MED CTR SAN FRANCISCO · PI BIKLE, DANIEL DAVID · 2011 to 2014
–
BLRD VA I01 BX001066BLRD VA I01 BX003814NCRR NIH HHS P41 RR001614NIAMS NIH HHS R01 AR038386NIAMS NIH HHS R01 AR050023NIDCR NIH HHS R03 DE018001NIDCR NIH HHS R21 DE019529
6 · The paper itself

Abstract

Previous studies have shown that dietary calcium suppresses oral carcinogenesis, but the mechanism is unclear. p120-catenin (p120) is a cytoplasmic protein closely associated with E-cadherin to form the E-cadherin-β-catenin complex and may function as a tumor suppressor in the oral epithelium. To determine whether p120 is involved in the mechanism by which dietary calcium suppresses oral carcinogenesis, The normal, low, or high calcium diet was fed control mice (designated as floxed p120 mice) or mice in which p120 was specifically deleted in the oral squamous epithelium during the adult stage (designated as p120cKO mice). All mice were exposed to a low dose of oral cancer carcinogen 4-nitroquinoline 1-oxide and rates of oral squamous cell carcinoma (OSCC) and proliferation and differentiation in the cancerous and non-cancerous oral epithelium of these mice were examined. The results showed that the low calcium diet increased rates of OSCC and proliferation of the non-cancerous oral epithelium and decreased differentiation of the non-cancerous oral epithelium, but had no effect on cancerous oral epithelium. In contrast, the high calcium diet had opposite effects. However, the effect of the dietary calcium on the rates of OSCC, proliferation, and differentiation of the non-cancerous epithelium were not seen in p120cKO mice. Based on these results, we conclude that p120 is required for dietary calcium suppression of oral carcinogenesis and oral epithelial proliferation and dietary calcium induction of oral epithelial differentiation. J. Cell. Physiol. 232: 1360-1367, 2017. © 2016 Wiley Periodicals, Inc.

Indexed as

4-Nitroquinoline-1-oxideAnimalsCalciumCalcium, DietaryCarcinogenesisCarcinoma, Squamous CellCateninsCell DifferentiationCell ProliferationDelta CateninEpitheliumGene DeletionMice, Inbred C57BLMice, KnockoutMouth NeoplasmsNeoplasm Invasiveness4-Nitroquinoline-1-oxide4-nitroquinolone-1-oxideCalciumCalcium, DietaryCateninsCtnnd1 protein, mouseDelta CateninParathyroid HormonePhosphorusQuinolonesTamoxifen

Identifiers

PMID27682597
PMCPMC9000997
OpenAlexW2525901122

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.