Evidence map›Paper›PMID 27682203›Full record

ReviewFASEB journal : official publication of the Federation of American Societies for Experimental Biology2017

Considering sex as a biological variable in preclinical research.

Leah R Miller, Cheryl Marks, Jill B Becker, Patricia D Hurn, Wei-Jung Chen, Teresa Woodruff, Margaret M McCarthy, Farida Sohrabji, Londa Schiebinger, Cora Lee Wetherington and 8 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 235 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
235citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

235 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
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  4. Reporting of sex as a variable in cardiovascular studies using cultured cells: A systematic review.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020
    Pooled it
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  15. Hepatic cellular stress response pathways exhibit species differences in basal and inducible activity.Toxicological sciences : an official journal of the Society of Toxicology · 2026
    Article
  16. A dual role of hippocampal perineuronal nets in plasticity and protection is revealed by improvement and impairment of diet-induced memory dysfunction.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
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175 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Leah R MillerOffice of Research on Women's Health, National Institutes of Health, Bethesda, Maryland, USA; leah.miller@nih.gov.
Cheryl MarksDivision of Cancer Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Jill B BeckerMolecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, Michigan, USA.
Patricia D HurnSchool of Nursing, University of Michigan, Ann Arbor, Michigan, USA.
Wei-Jung ChenDepartment of Neuroscience and Experimental Therapeutics, Texas A&M Health Science Center, Bryan, Texas, USA.
Teresa WoodruffWomen's Health Research Institute, Northwestern University, Chicago, Illinois, USA.
Margaret M McCarthyDepartment of Pharmacology, University of Maryland, Baltimore, Maryland, USA.
Farida SohrabjiDepartment of Neuroscience and Experimental Therapeutics, Texas A&M Health Science Center, Bryan, Texas, USA.
Londa SchiebingerHistory of Science, Stanford University, Stanford, California, USA.
Cora Lee WetheringtonNational Institute on Drug Abuse, National Institutes of Health, Bethesda, Maryland, USA.
Susan MakrisOffice of Research and Development, National Center for Environmental Assessment, U.S. Environmental Protection Agency, Washington, D.C., USA.
Arthur P ArnoldDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, California, USA.
Gillian EinsteinDepartment of Psychology, University of Toronto, Toronto, Ontario, Canada.
Virginia M MillerDepartment of Surgery and Physiology, Mayo Clinic, Rochester, Minnesota, USA.
Kathryn SandbergDepartment of Medicine, Georgetown University Medical Center, Washington, D.C., USA.
Susan MaierOffice of Research on Women's Health, National Institutes of Health, Bethesda, Maryland, USA.
Terri L CornelisonOffice of Research on Women's Health, National Institutes of Health, Bethesda, Maryland, USA.
Janine A ClaytonOffice of Research on Women's Health, National Institutes of Health, Bethesda, Maryland, USA.

Funding

Northwestern University Clinical and Translational Science Institute (NUCATS)UL1TR001422 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI D'AQUILA, RICHARD · 2015 to 2023
$56.8M
Sex-specific Risk for Vascular Dysfunction and Cognitive DeclineP50AG044170 · NIA · MAYO CLINIC ROCHESTER · PI MILLER, VIRGINIA M · 2012 to 2017
$6.1M
Immune Modulation of HypertensionR01HL119380 · NHLBI · GEORGETOWN UNIVERSITY · PI SANDBERG, KATHRYN L · 2015 to 2018
$2.4M
Genetic Mechanisms in Klinefelter Syndrome-Related BehaviorsR01HD076125 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARNOLD, ARTHUR P, JENTSCH, J. DAVID · 2014 to 2018
$2.3M
Epigenetic regulation of myocardial ischemia/reperfusion injury by X chromosomeR01HL131182 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARNOLD, ARTHUR P, EGHBALI, MANSOUREH · 2016 to 2019
$1.5M
NCATS NIH HHS UL1 TR001422NHLBI NIH HHS R01 HL119380NHLBI NIH HHS R01 HL131182NIA NIH HHS P50 AG044170NICHD NIH HHS R01 HD076125
6 · The paper itself

Abstract

In June 2015, the National Institutes of Health (NIH) released a Guide notice (NOT-OD-15-102) that highlighted the expectation of the NIH that the possible role of sex as a biologic variable be factored into research design, analyses, and reporting of vertebrate animal and human studies. Anticipating these guidelines, the NIH Office of Research on Women's Health, in October 2014, convened key stakeholders to discuss methods and techniques for integrating sex as a biologic variable in preclinical research. The workshop focused on practical methods, experimental design, and approaches to statistical analyses in the use of both male and female animals, cells, and tissues in preclinical research. Workshop participants also considered gender as a modifier of biology. This article builds on the workshop and is meant as a guide to preclinical investigators as they consider methods and techniques for inclusion of both sexes in preclinical research and is not intended to prescribe exhaustive/specific approaches for compliance with the new NIH policy.-Miller, L. R., Marks, C., Becker, J. B., Hurn, P. D., Chen, W.-J., Woodruff, T., McCarthy, M. M., Sohrabji, F., Schiebinger, L., Wetherington, C. L., Makris, S., Arnold, A. P., Einstein, G., Miller, V. M., Sandberg, K., Maier, S., Cornelison, T. L., Clayton, J. A. Considering sex as a biological variable in preclinical research.

Indexed as

Drug Evaluation, PreclinicalBiomedical ResearchFemaleHumansMaleNational Institutes of Health (U.S.)Sex FactorsUnited Statesgendermethodssex differencessex influences

Identifiers

PMID27682203
PMCPMC6191005

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.