ArticleMicroorganisms2015
Dynamic In Vitro Models of the Human Gastrointestinal Tract as Relevant Tools to Assess the Survival of Probiotic Strains and Their Interactions with Gut Microbiota.
Article in Microorganisms, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 88 citations in OpenAlex.
- Meta-analysis of the Microbial Diversity Cultured in Bioreactors Simulating the Gut Microbiome.Microbial ecology · 2024Pooled it
- Recovery ofNutrients · 2020Trial
- Isolation and Identification of a Canine-Derived Lactic Acid Bacterium with Probiotic Potential for Salmonellosis Prevention and Treatment.Probiotics and antimicrobial proteins · 2026Article
- Persistence of norovirus in static and dynamic simulators of the human gastrointestinal tract.Frontiers in microbiology · 2026Article
- Survival ofFoods (Basel, Switzerland) · 2025Article
- Whole-genome analysis of Bacillus paranthracis YC06 isolated from healthy individual feces for biodegrading inosine and guanosine.BMC microbiology · 2025Article
- Article
- A yeast-based oral therapeutic delivers immune checkpoint inhibitors to reduce intestinal tumor burden.Cell chemical biology · 2025Article
- Microbiota and metabolome dynamics induced by Shiga toxin-producingMicrobial cell (Graz, Austria) · 2025Article
- In Vitro Cholesterol Uptake by the Microflora of Selected Kefir Starter Cultures.Life (Basel, Switzerland) · 2024Article
- Impact of Western Diet on EnterohemorrhagicNutrients · 2024Article
- In Vitro Human Gastrointestinal Tract Simulation Systems: A Panoramic Review.Probiotics and antimicrobial proteins · 2024Review
- Characterization of the Effects of a Novel Probiotic onAnimals : an open access journal from MDPI · 2024Article
- Effect of Digested Selected Food Items on Markers of Oxidative Stress and Inflammation in a Caco-2-Based Human Gut Epithelial Model.Antioxidants (Basel, Switzerland) · 2024Article
- Article
- Biomaterials and Encapsulation Techniques for Probiotics: Current Status and Future Prospects in Biomedical Applications.Nanomaterials (Basel, Switzerland) · 2023Review
- Transfer of the Integrative and Conjugative Element ICEMicrobiology spectrum · 2023Article
- Impact Assessment of vB_KpnP_K1-ULIP33 Bacteriophage on the Human Gut Microbiota Using a Dynamic In Vitro Model.Viruses · 2023Article
- Study of the persistence and dynamics of recombinant mCherry-producing Yarrowia lipolytica strains in the mouse intestine using fluorescence imaging.Microbial biotechnology · 2023Article
- Evaluation of Different Advanced Approaches to Simulation of Dynamic In Vitro Digestion of Polyphenols from Different Food Matrices-A Systematic Review.Antioxidants (Basel, Switzerland) · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The beneficial effects of probiotics are conditioned by their survival during passage through the human gastrointestinal tract and their ability to favorably influence gut microbiota. The main objective of this study was to use dynamic in vitro models of the human digestive tract to investigate the effect of fasted or fed state on the survival kinetics of the new probiotic Saccharomyces cerevisiae strain CNCM I-3856 and to assess its influence on intestinal microbiota composition and activity. The probiotic yeast showed a high survival rate in the upper gastrointestinal tract whatever the route of admistration, i.e., within a glass of water or a Western-type meal. S. cerevisiae CNCM I-3856 was more sensitive to colonic conditions, as the strain was not able to colonize within the bioreactor despite a twice daily administration. The main bacterial populations of the gut microbiota, as well as the production of short chain fatty acids were not influenced by the probiotic treatment. However, the effect of the probiotic on the gut microbiota was found to be individual dependent. This study shows that dynamic in vitro models can be advantageously used to provide useful insight into the behavior of probiotic strains in the human digestive environment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.