ReviewMicroorganisms2015
Role of Bacterial Exopolysaccharides as Agents in Counteracting Immune Disorders Induced by Herpes Virus.
Review in Microorganisms, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 40 citations in OpenAlex.
- Production and Structural/Physicochemical Characteristics of Exopolysaccharides from the Halotolerant Strain Oceanobacillus sp. DT-Z6.Applied biochemistry and biotechnology · 2026Article
- EPS T14 fromImmunoTargets and therapy · 2024Article
- Anti-Bacterial Adhesion on Abiotic and Biotic Surfaces of the Exopolysaccharide from the Marine Bacillus licheniformis B3-15.Marine drugs · 2023Article
- The Regulation of Micro-Organisms' Extra-Cellular Polysaccharides on Immunity: A Meta-Analysis.Foods (Basel, Switzerland) · 2022Article
- Review
- Extraction and characterization of an exopolysaccharide from a marine bacterium.International microbiology : the official journal of the Spanish Society for Microbiology · 2022Article
- Isolation and characterization of an exopolymer produced by Bacillus licheniformis: In vitro antiviral activity against enveloped viruses.Carbohydrate polymers · 2020Article
- Anti-Inflammatory Activity of Exopolysaccharides fromBiomolecules · 2020Article
- Antiviral Activity of Exopolysaccharides Produced by Lactic Acid Bacteria of the GeneraMedicina (Kaunas, Lithuania) · 2019Article
- Marine Bacterial Exopolymers-Mediated Green Synthesis of Noble Metal Nanoparticles with Antimicrobial Properties.Polymers · 2019Article
- Production and characterization of exopolysaccharides by Geobacillus thermodenitrificans ArzA-6 and Geobacillus toebii ArzA-8 strains isolated from an Armenian geothermal spring.Extremophiles : life under extreme conditions · 2018Article
- Microbial Diversity in Extreme Marine Habitats and Their Biomolecules.Microorganisms · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Extreme marine environments, such as the submarine shallow vents of the Eolian Islands (Italy), offer an almost unexplored source of microorganisms producing unexploited and promising biomolecules for pharmaceutical applications. Thermophilic and thermotolerant bacilli isolated from Eolian vents are able to produce exopolysaccharides (EPSs) with antiviral and immunomodulatory effects against Herpes simplex virus type 2 (HSV-2). HSV-2 is responsible for the most common and continuously increasing viral infections in humans. Due to the appearance of resistance to the available treatments, new biomolecules exhibiting different mechanisms of action could provide novel agents for treating viral infections. The EPSs hinder the HSV-2 replication in human peripheral blood mononuclear cells (PBMC) but not in WISH (Wistar Institute Susan Hayflic) cells line, indicating that cell-mediated immunity was involved in the antiviral activity. High levels of Th1-type cytokines were detected in PBMC treated with all EPSs, while Th2-type cytokines were not induced. These EPSs are water soluble exopolymers able to stimulate the immune response and thus contribute to the antiviral immune defense, acting as immunomodulators. As stimulants of Th1 cell-mediated immunity, they could lead to the development of novel drugs as alternative in the treatment of herpes virus infections, as well as in immunocompromised host.
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