Evidence map›Paper›PMID 27681930›Full record

ReviewMicroorganisms2016

Adhesion Properties of Lactic Acid Bacteria on Intestinal Mucin.

Keita Nishiyama, Makoto Sugiyama, Takao Mukai

Open access · goldAbstract readReview
In one paragraph

Review in Microorganisms, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.

0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed
15.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

83 citing papers in PubMed, 169 citations in OpenAlex.

  1. Microbiology spectrum · 2025
    Trial
  2. Article
  3. Review
  4. Review
  5. Induction of Human β-Defensin-2 by VaginalOpen forum infectious diseases · 2026
    Article
  6. Review
  7. Article
  8. Article
  9. Functional and Genomic Analysis ofJournal of microbiology and biotechnology · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

23 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Keita NishiyamaDepartment of Microbiology, School of Pharmacy, Kitasato University, Tokyo 108-8641, Japan. nishiyamak@pharm.kitasato-u.ac.jp.
Makoto SugiyamaFaculty of Veterinary Medicine, School of Veterinary Medicine, Kitasato University, Aomori 034-8628, Japan. masugi@vmas.kitasato-u.ac.jp.
Takao MukaiDepartment of Animal Science, School of Veterinary Medicine, Kitasato University, Aomori 034-8628, Japan. mukai@vmas.kitasato-u.ac.jp.
Kitasato University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lactic acid bacteria (LAB) are Gram-positive bacteria that are natural inhabitants of the gastrointestinal (GI) tracts of mammals, including humans. Since Mechnikov first proposed that yogurt could prevent intestinal putrefaction and aging, the beneficial effects of LAB have been widely demonstrated. The region between the duodenum and the terminal of the ileum is the primary region colonized by LAB, particularly the Lactobacillus species, and this region is covered by a mucus layer composed mainly of mucin-type glycoproteins. The mucus layer plays a role in protecting the intestinal epithelial cells against damage, but is also considered to be critical for the adhesion of Lactobacillus in the GI tract. Consequently, the adhesion exhibited by lactobacilli on mucin has attracted attention as one of the critical factors contributing to the persistent beneficial effects of Lactobacillus in a constantly changing intestinal environment. Thus, understanding the interactions between Lactobacillus and mucin is crucial for elucidating the survival strategies of LAB in the GI tract. This review highlights the properties of the interactions between Lactobacillus and mucin, while concomitantly considering the structure of the GI tract from a histochemical perspective.

Indexed as

adhesioncarbohydratecolonizationgastrointestinal tracthistochemistrylactic acid bacteriamucin

Identifiers

PMID27681930
PMCPMC5039594
OpenAlexW2521786704

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.