Evidence map›Paper›PMID 27681914›Full record

ReviewMicroorganisms2016

Microbiome, Metabolome and Inflammatory Bowel Disease.

Ishfaq Ahmed, Badal C Roy, Salman A Khan, Seth Septer, Shahid Umar

Open access · goldAbstract readReview
In one paragraph

Review in Microorganisms, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 114 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
114citing papers in PubMed, 3 pooled it
5.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

114 citing papers in PubMed, 3 syntheses or guidelines pooled it, 188 citations in OpenAlex.

  1. Pooled it
  2. The Human Respiratory Microbiome: Current Understandings and Future Directions.American journal of respiratory cell and molecular biology · 2023
    Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Polysaccharide fromFoods (Basel, Switzerland) · 2026
    Article
  7. Article
  8. Review
  9. mBio · 2025
    Article
  10. Heat-killedJournal of clinical biochemistry and nutrition · 2025
    Article
  11. Review
  12. Article
  13. Article
  14. Emotional Disturbances and Crohn's Disease.Clinical practice and epidemiology in mental health : CP & EMH · 2025
    Review
  15. Article
  16. Review
  17. Article
  18. Review
  19. Bacteroides fragilis in saliva: investigating links with ulcerative colitis.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024
    Article
  20. Article

54 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Ishfaq AhmedDepartment of Surgery, University of Kansas Medical Center, 3901 Rainbow Blvd, 4028 Wahl Hall East, Kansas City, KS 66160, USA. iahmed@kumc.edu.
Badal C RoyDepartment of Surgery, University of Kansas Medical Center, 3901 Rainbow Blvd, 4028 Wahl Hall East, Kansas City, KS 66160, USA. broy@kumc.edu.
Salman A KhanDepartment of Internal Medicine and Department of Pediatrics, University of Missouri, Kansas City, MO 64110, USA. khansal@umkc.edu.
Seth SepterDepartment of Internal Medicine and Department of Pediatrics, University of Missouri, Kansas City, MO 64110, USA. ssepter@cmh.edu.
Shahid UmarDepartment of Surgery, University of Kansas Medical Center, 3901 Rainbow Blvd, 4028 Wahl Hall East, Kansas City, KS 66160, USA. sumar@kumc.edu.
University of Kansas Medical Center · USUniversity of Missouri–Kansas City · US

Funding

Epigenetics and Infection-induced EMT of Colonic Crypts - Target for ChemopreventionR01CA185322 · NCI · UNIVERSITY OF KANSAS MEDICAL CENTER · PI UMAR, SHAHID · 2015 to 2019
$1.9M
NCI NIH HHS R01 CA185322
6 · The paper itself

Abstract

Inflammatory Bowel Disease (IBD) is a multifactorial disorder that conceptually occurs as a result of altered immune responses to commensal and/or pathogenic gut microbes in individuals most susceptible to the disease. During Crohn's Disease (CD) or Ulcerative Colitis (UC), two components of the human IBD, distinct stages define the disease onset, severity, progression and remission. Epigenetic, environmental (microbiome, metabolome) and nutritional factors are important in IBD pathogenesis. While the dysbiotic microbiota has been proposed to play a role in disease pathogenesis, the data on IBD and diet are still less convincing. Nonetheless, studies are ongoing to examine the effect of pre/probiotics and/or FODMAP reduced diets on both the gut microbiome and its metabolome in an effort to define the healthy diet in patients with IBD. Knowledge of a unique metabolomic fingerprint in IBD could be useful for diagnosis, treatment and detection of disease pathogenesis.

Indexed as

dysbiosisinflammation bowel diseasesmetabolitesmetabolomemicrobiomeprebioticsprobiotics

Identifiers

PMID27681914
PMCPMC5029486
OpenAlexW2426105576

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.