Evidence map›Paper›PMID 27681877›Full record

GuidelineEuropean journal of cancer (Oxford, England : 1990)2016

Community acquired respiratory virus infections in cancer patients-Guideline on diagnosis and management by the Infectious Diseases Working Party of the German Society for haematology and Medical Oncology.

Marie von Lilienfeld-Toal, Annemarie Berger, Maximilian Christopeit, Marcus Hentrich, Claus Peter Heussel, Jana Kalkreuth, Michael Klein, Matthias Kochanek, Olaf Penack, Elke Hauf and 8 more

Open access · greenAbstract readPractice GuidelineReview
In one paragraph

Guideline in European journal of cancer (Oxford, England : 1990), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 4 pooled it
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 4 syntheses or guidelines pooled it, 91 citations in OpenAlex.

  1. Guideline
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  9. Predictors of antibiotic prescription for upper respiratory infections in cancer patients.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2025
    Article
  10. Article
  11. Microbiological risk factors, ICU survival, and 1-year survival in hematological patients with pneumonia requiring invasive mechanical ventilation.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2024
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  12. Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. [Management of infections in patients with cancer].Der Onkologe : Organ der Deutschen Krebsgesellschaft e.V · 2022
    Article
  18. Article
  19. Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 15 institutions in 1 country.

Marie von Lilienfeld-ToalDepartment of Haematology and Medical Oncology, Jena University Hospital, Jena, Germany; Centre for Sepsis Control and Care (CSCC), University Hospital Jena, Germany; Leibniz Institute for Natural Product Research and Infection Biology, Hans-Knöll-Institut, Jena, Germany. Electronic address: Marie.von_Lilienfeld-Toal@med.uni-jena.de.
Annemarie BergerInstitute for Medical Virology, University Hospital Frankfurt, Goethe University Frankfurt, Germany.
Maximilian ChristopeitDepartment of Stem Cell Transplantation, University Hospital Hamburg-Eppendorf, Hamburg, Germany.
Marcus HentrichDepartment of Haematology and Oncology, Red Cross Hospital, Munich, Germany.
Claus Peter HeusselDepartment of Diagnostic and Interventional Radiology, University Hospital, Heidelberg, Germany; Translational Lung Research Center Heidelberg (TLRC), Member of the German Center for Lung Research (DZL), Heidelberg, Germany; Department of Diagnostic and Interventional Radiology with Nuclear Medicine, Thoraxklinik at University of Heidelberg, Heidelberg, Germany.
Jana KalkreuthDepartment of Haematology and Medical Oncology, Jena University Hospital, Jena, Germany.
Michael KleinDepartment I of Internal Medicine, Prosper-Hospital, Recklinghausen, Germany.
Matthias KochanekDepartment I of Internal Medicine, University Hospital of Cologne, Cologne, Germany.
Olaf PenackDepartment of Hematology, Oncology and Tumorimmunology, Charité Campus Virchow, Berlin, Germany.
Elke HaufDepartment III of Internal Medicine, The University Hospital Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
Christina RiegerLehrpraxis der Ludwig-Maximilians-Universität München, Germering, Germany.
Gerda SillingDepartment of Haematology, Oncology and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University, Aachen, Germany.
Maria VehreschildDepartment I of Internal Medicine, University Hospital of Cologne, Cologne, Germany; German Centre for Infection Research, Partner Site Bonn-Cologne, Cologne, Germany.
Thomas WeberDepartment of Hematology and Oncology, Martin-Luther-University Halle-Wittenberg, Halle, Germany.
Hans-Heinrich WolfDepartment of Hematology and Oncology, Martin-Luther-University Halle-Wittenberg, Halle, Germany.
Nicola LehnersDepartment of Haematology and Oncology, University Hospital of Heidelberg, Heidelberg, Germany.
Enrico SchalkDepartment of Haematology and Oncology, Medical Centre, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.
Karin MayerDepartment of Haematology and Oncology, University Hospital Bonn, Bonn, Germany.
Heidelberg University · DEJena University Hospital · DEMartin Luther University Halle-Wittenberg · DECharité - Universitätsmedizin Berlin · DEGerman Center for Infection Research · DEGerman Red Cross · DEKlinikum rechts der Isar · DELudwig-Maximilians-Universität München · DEOtto-von-Guericke University Magdeburg · DEProsper Hospital · DERWTH Aachen University · DEUniversität Hamburg · DEUniversity Hospital Bonn · DEUniversity Hospital Cologne · DEUniversity Hospital Frankfurt · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCommunity acquired viruses (CRVs) may cause severe disease in cancer patients. Thus, efforts should be made to diagnose CRV rapidly and manage CRV infections accordingly.

methodsA panel of 18 clinicians from the Infectious Diseases Working Party of the German Society for Haematology and Medical Oncology have convened to assess the available literature and provide recommendations on the management of CRV infections including influenza, respiratory syncytial virus, parainfluenza virus, human metapneumovirus and adenovirus.

resultsCRV infections in cancer patients may lead to pneumonia in approximately 30% of the cases, with an associated mortality of around 25%. For diagnosis of a CRV infection, combined nasal/throat swabs or washes/aspirates give the best results and nucleic acid amplification based-techniques (NAT) should be used to detect the pathogen. Hand hygiene, contact isolation and face masks have been shown to be of benefit as general infection management. Causal treatment can be given for influenza, using a neuraminidase inhibitor, and respiratory syncytial virus, using ribavirin in addition to intravenous immunoglobulins. Ribavirin has also been used to treat parainfluenza virus and human metapneumovirus, but data are inconclusive in this setting. Cidofovir is used to treat adenovirus pneumonitis.

conclusionsCRV infections may pose a vital threat to patients with underlying malignancy. This guideline provides information on diagnosis and treatment to improve the outcome.

Indexed as

Adenovirus Infections, HumanAntiviral AgentsCidofovirCommunity-Acquired InfectionsCytosineGermanyHand HygieneHumansImmunoglobulins, IntravenousImmunologic FactorsInfluenza, HumanLungMasksMedical OncologyMetapneumovirusNeoplasmsAntiviral AgentsCidofovirCytosineImmunoglobulins, IntravenousImmunologic FactorsNeuraminidaseOrganophosphonatesOseltamivirRibavirinInfluenzaParainfluenzaPneumoniaRespiratory syncytial virusSuperinfectionUpper respiratory tract infection

Identifiers

PMID27681877
PMCPMC7125955
OpenAlexW2521384011

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.