Evidence map›Paper›PMID 27681813›Full record

Trial reportMusculoskeletal surgery2017

Clinical comparison of oral administration and viscosupplementation of hyaluronic acid (HA) in early knee osteoarthritis.

M Ricci, G M Micheloni, M Berti, F Perusi, E Sambugaro, E Vecchini, B Magnan

Abstract readComparative StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Musculoskeletal surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 43 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Review
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  5. Roles of metabolic dysregulation in osteoarthritis.Frontiers in cell and developmental biology · 2026
    Review
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  12. Review
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  19. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

M RicciOrthopedic and Traumatology Unit, Surgery Department, University of Verona, 37126, Polo Confortini, Verona, Italy.
G M MicheloniOrthopedic and Traumatology Unit, Surgery Department, University of Verona, 37126, Polo Confortini, Verona, Italy. gianmario.micheloni@libero.it.
M BertiOrthopedic and Traumatology Unit, Surgery Department, University of Verona, 37126, Polo Confortini, Verona, Italy.
F PerusiOrthopedic and Traumatology Unit, Ospedale di Rovereto, Trento, Italy.
E SambugaroOrthopedic and Traumatology Unit, Surgery Department, University of Verona, 37126, Polo Confortini, Verona, Italy.
E VecchiniOrthopedic and Traumatology Unit, Surgery Department, University of Verona, 37126, Polo Confortini, Verona, Italy.
B MagnanOrthopedic and Traumatology Unit, Surgery Department, University of Verona, 37126, Polo Confortini, Verona, Italy.
University of Verona · ITCenter for Neuroscience and Cognitive Systems · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeOsteoarthritis (OA) is a progressive, chronic and degenerative joint disease characterized by a loss of articular cartilage. Treatment of OA is largely palliative based on nonsteroidal anti-inflammatory drugs, opioids and injections of steroids. Regarding conservative treatment, intra-articular injections of hyaluronic acid (HA) can play a role in early symptomatic knee OA. MATERIALS AND

methodsBetween August 2015 and September 2015, sixty patients (32 males and 28 females) between 40 and 70 years old were randomly allocated into two groups: Half were treated with three weekly intra-articular injections of hyaluronic acid 1.6 % (group A), while the others were treated with Syalox 300 Plus

resultsAKSS of the patients in both groups was significantly increased by the treatment, and VAS score was significantly reduced. In both groups, two subgroups were created with patients older than 60 years and patients younger than 60 years. Better results are reported in younger patients of group A and older subjects in group B.

conclusionsDespite several limitations, the results of the study have shown that HA injection and oral administration may have beneficial therapeutic effects on patients with early osteoarthritis. Different outcomes in younger and older subject suggested a combined therapy first with local infiltrations and then with oral composition.

Indexed as

Administration, OralAdultAgedEarly DiagnosisFemaleHumansHyaluronic AcidInjections, Intra-ArticularMaleMiddle AgedOsteoarthritis, KneePain MeasurementRetrospective StudiesTreatment OutcomeViscosupplementsHyaluronic AcidViscosupplementsEarly knee osteoarthritisHyaluronic acidViscosupplementation

Identifiers

PMID27681813
OpenAlexW2525285693

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.