ArticleProceedings of the National Academy of Sciences of the United States of America2016
Bursts of activity in collective cell migration.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Substrate heterogeneity promotes cancer cell dissemination through interface roughening.Science advances · 2026Article
- A self-assembled protein β-helix as a self-contained biofunctional motif.Nature communications · 2025Article
- Vertex model with internal dissipation enables sustained flows.Nature communications · 2025Article
- Beehive scale-free emergent dynamics.Scientific reports · 2024Article
- E-cadherin biomaterials reprogram collective cell migration and cell cycling by forcing homeostatic conditions.Cell reports · 2024Article
- Beehive scale-free emergent dynamics.ArXiv · 2023Article
- Anomalous Self-Organization in Active Piles.Entropy (Basel, Switzerland) · 2023Article
- Methodology for comprehensive cell-level analysis of wound healing experiments using deep learning in MATLAB.BMC molecular and cell biology · 2021Article
- Cell cycle-dependent active stress drives epithelia remodeling.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- MicroRNA-222 Regulates Melanoma Plasticity.Journal of clinical medicine · 2020Article
- Chromatin and Cytoskeletal Tethering Determine Nuclear Morphology in Progerin-Expressing Cells.Biophysical journal · 2020Article
- Dense active matter model of motion patterns in confluent cell monolayers.Nature communications · 2020Article
- Is cell migration a selectable trait in the natural evolution of cancer development?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Article
- Uncoupling Traditional Functionalities of Metastasis: The Parting of Ways with Real-Time Assays.Journal of clinical medicine · 2019Review
- Active wetting of epithelial tissues.Nature physics · 2019Article
- Avalanches and extreme value statistics in interfacial crackling dynamics.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2018Article
- Migratory Metrics of Wound Healing: A Quantification Approach forFrontiers in oncology · 2018Article
- Collective cell migration has distinct directionality and speed dynamics.Cellular and molecular life sciences : CMLS · 2017Article
- Are Tumor Cell Lineages Solely Shaped by Mechanical Forces?Bulletin of mathematical biology · 2017Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
Dense monolayers of living cells display intriguing relaxation dynamics, reminiscent of soft and glassy materials close to the jamming transition, and migrate collectively when space is available, as in wound healing or in cancer invasion. Here we show that collective cell migration occurs in bursts that are similar to those recorded in the propagation of cracks, fluid fronts in porous media, and ferromagnetic domain walls. In analogy with these systems, the distribution of activity bursts displays scaling laws that are universal in different cell types and for cells moving on different substrates. The main features of the invasion dynamics are quantitatively captured by a model of interacting active particles moving in a disordered landscape. Our results illustrate that collective motion of living cells is analogous to the corresponding dynamics in driven, but inanimate, systems.
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