Evidence map›Paper›PMID 27681572›Full record

ArticleTrials2016

STEPWISE - STructured lifestyle Education for People WIth SchizophrEnia: a study protocol for a randomised controlled trial.

Rebecca Gossage-Worrall, Richard I G Holt, Katharine Barnard, Marian E Carey, Melanie J Davies, Chris Dickens, Yvonne Doherty, Charlotte Edwardson, Paul French, Fiona Gaughran and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Non-pharmacologicaL InterVEntions for Antipsychotic-Induced Weight Gain (RESOLVE) in People Living With Severe Mental Illness: A Realist Synthesis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025
    Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Rebecca Gossage-WorrallThe University of Sheffield, Sheffield, UK. r.gossage-worrall@sheffield.ac.uk.ORCID http://orcid.org/0000-0002-1435-9474
Richard I G HoltHuman Development and Health Academic Unit, University of Southampton Faculty of Medicine, Southampton, SO16 6YD, UK.
Katharine BarnardHuman Development and Health Academic Unit, University of Southampton Faculty of Medicine, Southampton, SO16 6YD, UK.
Marian E CareyLeicester Diabetes Centre, University Hospitals of Leicester NHS Trust, Leicester, UK.
Melanie J DaviesDiabetes Research Centre, University of Leicester, Leicester, UK.
Chris DickensUniversity of Exeter Medical School and NIHR Collaboration for Leadership in Applied Health Research and Care (CLAHRC) for the South West Peninsula, Exeter, UK.
Yvonne DohertyLeicester Diabetes Centre, University Hospitals of Leicester NHS Trust, Leicester, UK.
Charlotte EdwardsonDiabetes Research Centre, University of Leicester, Leicester, UK.
Paul FrenchGreater Manchester West NHS Foundation Trust, Manchester, UK.
Fiona GaughranSouth London and Maudsley NHS Foundation Trust, London, UK.
Kathryn GreenwoodR&D, Sussex Partnership NHS Foundation Trust; and, School of Psychology, University of Sussex, Brighton, UK.
Sridevi KalidindiSouth London and Maudsley NHS Foundation Trust, London, UK.
Daniel HindThe University of Sheffield, Sheffield, UK.
Kamlesh KhuntiDiabetes Research Centre, University of Leicester, Leicester, UK.
Paul McCroneKings College London, London, UK.
Jonathan MitchellSheffield Health and Social Care NHS Foundation Trust, Sheffield, UK.
John PendleburyGreater Manchester West NHS Foundation Trust, Manchester, UK.
Shanaya RathodSouthern Health NHS Foundation Trust, Southampton, UK.
David ShiersCarer; former GP, North Staffordshire; Honorary Reader in the Division of Psychology and Mental Health at the University of Manchester, Manchester, UK.
Najma SiddiqiBradford District Care Trust, Bradford, UK.
Lizzie SwabyThe University of Sheffield, Sheffield, UK.
Stephen WrightLeeds and York Partnership NHS Foundation Trust, Leeds, UK.

Funding

Department of Health 12/28/05
6 · The paper itself

Abstract

backgroundPeople with schizophrenia are two to three times more likely to be overweight than the general population. The UK National Institute of Health and Care Excellence (NICE) recommends an annual physical health review with signposting to, or provision of, a lifestyle programme to address weight concerns and obesity. The purpose of this randomised controlled trial is to assess whether a group-based structured education programme can help people with schizophrenia to lose weight.

methodsDesign: a randomised controlled trial of a group-based structured education programme.

setting10 UK community mental health trusts.

participants396 adults with schizophrenia, schizoaffective, or first-episode psychosis who are prescribed antipsychotic medication will be recruited. Participants will be overweight, obese or be concerned about their weight.

interventionparticipants will be randomised to either the intervention or treatment as usual (TAU). The intervention arm will receive TAU plus four 2.5-h weekly sessions of theory-based lifestyle structured group education, with maintenance contact every 2 weeks and 'booster' sessions every 3 months. All participants will receive standardised written information about healthy eating, physical activity, alcohol and smoking. OUTCOMES: the primary outcome is weight (kg) change at 1 year post randomisation. Secondary outcomes, which will be assessed at 3 and 12 months, include: the proportion of participants who maintained or reduced their weight; waist circumference; body mass index; objectively measured physical activity (wrist accelerometer); self-reported diet; blood pressure; fasting plasma glucose, lipid profile and HbA DISCUSSION: The STEPWISE trial will provide evidence for the clinical and cost-effectiveness of a tailored intervention, which, if successful, could be implemented rapidly in the NHS.

trial registrationISRCTN19447796 , registered on 20 March 2014.

Indexed as

Antipsychotic medicationBehaviour changeEducationFirst-episode psychosisLifestyleObesityOverweightSchizophrenia

Identifiers

PMID27681572
PMCPMC5041320

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.